ID   RELD1_HUMAN             Reviewed;         526 AA.
AC   A0A1B0GV85;
DT   28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 2.
DT   13-FEB-2019, entry version 20.
DE   RecName: Full=Reelin domain-containing protein 1 {ECO:0000305};
DE   Flags: Precursor;
GN   Name=REELD1 {ECO:0000312|HGNC:HGNC:53638};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 182-319.
RX   PubMed=11752456; DOI=10.1073/pnas.241522398;
RA   Xu X.R., Huang J., Xu Z.G., Qian B.Z., Zhu Z.D., Yan Q., Cai T.,
RA   Zhang X., Xiao H.S., Qu J., Liu F., Huang Q.H., Cheng Z.H., Li N.G.,
RA   Du J.J., Hu W., Shen K.T., Lu G., Fu G., Zhong M., Xu S.H., Gu W.Y.,
RA   Huang W., Zhao X.T., Hu G.X., Gu J.R., Chen Z., Han Z.G.;
RT   "Insight into hepatocellular carcinogenesis at transcriptome level by
RT   comparing gene expression profiles of hepatocellular carcinoma with
RT   those of corresponding noncancerous liver.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:15089-15094(2001).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AC097372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471056; EAX05028.1; -; Genomic_DNA.
DR   EMBL; AV698927; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS87268.1; -.
DR   UniGene; Hs.170876; -.
DR   BioMuta; ENSG00000250673; -.
DR   Ensembl; ENST00000636502; ENSP00000490412; ENSG00000250673.
DR   GeneCards; REELD1; -.
DR   HGNC; HGNC:53638; REELD1.
DR   neXtProt; NX_A0A1B0GV85; -.
DR   OpenTargets; ENSG00000250673; -.
DR   GeneTree; ENSGT00940000163277; -.
DR   PRO; PR:A0A1B0GV85; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   ExpressionAtlas; A0A1B0GV85; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd08544; Reeler; 1.
DR   InterPro; IPR002861; Reeler_dom.
DR   Pfam; PF02014; Reeler; 1.
DR   PROSITE; PS51019; REELIN; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24    526       Reelin domain-containing protein 1.
FT                                {ECO:0000255}.
FT                                /FTId=PRO_5010648591.
FT   TOPO_DOM     24    443       Extracellular. {ECO:0000305}.
FT   TRANSMEM    444    462       Helical. {ECO:0000255}.
FT   TOPO_DOM    463    526       Cytoplasmic. {ECO:0000305}.
FT   DOMAIN       24    179       Reelin. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00363}.
SQ   SEQUENCE   526 AA;  56837 MW;  FBA2EC75620E59D7 CRC64;
     MRMQAALVGW ACTTLCLASC SSAFSHGAST VACDDMQPKH IQAQPQHQDS HHITIHTHRT
     SYAPGDKIPV TVRSSRDFMG FLLQARRVSD HQIAGTFVLI PPHSKLMTCF QEADAVTHSD
     KSLKRNLSFV WKAPAQPVGD IKFLLSVVQS YFVYWARIES SVVSQQTHSS AHSDDRMEPR
     LLMPNLHQRL GDVEGAAPAP RTPITLPQQH THVFAVALPG AAEEDNLDPV PASIWVTKFP
     GDAETLSQPS SHTATEGSIN QQPSGDSNPT LEPSLEVHRL ERLVALKRVS SESFASSLST
     HHRTQDDPSF DSLETCLSSD GGEQDKTKAS NRTVTQPPLS TVQLTYPQCL WSSETFTGNG
     VRASNPIPVL QTSGTSGLPA AGDQSEASRA SASFLPQSKH KELRAGKGNG EGGVGYPRQT
     NPRPDIGLEG AQAPLGIQLR TPQLGILLCL SATLGMALAA GLRYLHTQYC HQQTEVSFSE
     PASDAVARSN SGETVHVRKI GENSFVLVQA EYNWITPSVG SKKTVL
//