ID   A0A1B0GUS1_HUMAN        Unreviewed;       159 AA.
AC   A0A1B0GUS1;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   RecName: Full=Autophagy protein 5 {ECO:0000256|RuleBase:RU361202};
GN   Name=ATG5 {ECO:0000313|Ensembl:ENSP00000490221};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490221, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490221, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000490221}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- FUNCTION: Involved in autophagic vesicle formation.
CC       {ECO:0000256|RuleBase:RU361202}.
CC   -!- SUBUNIT: Conjugated with ATG12. {ECO:0000256|RuleBase:RU361202}.
CC   -!- SUBCELLULAR LOCATION: Preautophagosomal structure membrane
CC       {ECO:0000256|RuleBase:RU361202}; Peripheral membrane protein
CC       {ECO:0000256|RuleBase:RU361202}.
CC   -!- SIMILARITY: Belongs to the ATG5 family.
CC       {ECO:0000256|RuleBase:RU361202}.
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DR   EMBL; AL022067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL133509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL138917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL358952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL672292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A1B0GUS1; -.
DR   PeptideAtlas; A0A1B0GUS1; -.
DR   Ensembl; ENST00000636335; ENSP00000490221; ENSG00000057663.
DR   HGNC; HGNC:589; ATG5.
DR   OpenTargets; ENSG00000057663; -.
DR   GeneTree; ENSGT00390000004766; -.
DR   ChiTaRS; ATG5; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   ExpressionAtlas; A0A1B0GUS1; baseline and differential.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   InterPro; IPR007239; Atg5.
DR   PANTHER; PTHR13040; PTHR13040; 1.
DR   Pfam; PF04106; APG5; 1.
PE   1: Evidence at protein level;
KW   Autophagy {ECO:0000256|RuleBase:RU361202};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Isopeptide bond {ECO:0000256|RuleBase:RU361202};
KW   Membrane {ECO:0000256|RuleBase:RU361202};
KW   Proteomics identification {ECO:0000213|EPD:A0A1B0GUS1,
KW   ECO:0000213|MaxQB:A0A1B0GUS1, ECO:0000213|PeptideAtlas:A0A1B0GUS1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Ubl conjugation {ECO:0000256|RuleBase:RU361202}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    159       Autophagy protein 5.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408665.
SQ   SEQUENCE   159 AA;  18474 MW;  2AADA04B3628B7A9 CRC64;
     MHYPIGLLFD LLASSSALPW NITVHFKSFP EKDLLHCPSK DAIEAHFMSC MKEADALKHK
     SQVINEMQKK DHKQLWMGLQ NDRFDQFWAI NRKLMEYPAE ENGFRYIPFR IYQTTTERPF
     IQKLFRPVAA DGQLHTLGDL LKEVCPSAID PEEIPPGED
//