ID   A0A1B0GU92_HUMAN        Unreviewed;       557 AA.
AC   A0A1B0GU92;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000490014};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490014, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000490014, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000490014}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01103,
CC       ECO:0000256|RuleBase:RU000454, ECO:0000256|SAAS:SAAS01079896}.
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DR   EMBL; AC068580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   BioMuta; ENSG00000250644; -.
DR   EPD; A0A1B0GU92; -.
DR   jPOST; A0A1B0GU92; -.
DR   Ensembl; ENST00000636615; ENSP00000490014; ENSG00000250644.
DR   GeneCards; ENSG00000250644; -.
DR   OpenTargets; ENSG00000250644; -.
DR   GeneTree; ENSGT00940000155733; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; A0A1B0GU92; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.70.10; -; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR13683; PTHR13683; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   Pfam; PF04505; CD225; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   1: Evidence at protein level;
KW   Aspartyl protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|SAAS:SAAS00670207};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454}; Membrane {ECO:0000256|SAM:Phobius};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01103,
KW   ECO:0000256|RuleBase:RU000454};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A1B0GU92};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    557       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408637.
FT   TRANSMEM    482    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    528    550       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       79    404       Peptidase A1.
FT                                {ECO:0000259|PROSITE:PS51767}.
FT   ACT_SITE     97     97       {ECO:0000256|PROSITE-ProRule:PRU01103}.
FT   ACT_SITE    295    295       {ECO:0000256|PROSITE-ProRule:PRU01103}.
FT   DISULFID    329    364       {ECO:0000256|PROSITE-ProRule:PRU01103}.
SQ   SEQUENCE   557 AA;  59860 MW;  DCE4D24435E522A7 CRC64;
     MQPSSLLPLA LCLLAAPASA LVRIPLHKFT SIRRTMSEVG GSVEDLIAKG PVSKYSQAVP
     AVTEGPIPEV LKNYMDAQYY GEIGIGTPPQ CFTVVFDTGS SNLWVPSIHC KLLDIACWIH
     HKYNSDKSST YVKNGTSFDI HYGSGSLSGY LSQDTVSVPC QSASSASALG GVKVERQVFG
     EATKQPGITF IAAKFDGILG MAYPRISVNN VLPVFDNLMQ QKLVDQNIFS FYLSRDPDAQ
     PGGELMLGGT DSKYYKGSLS YLNVTRKAYW QVHLDQVEVA SGLTLCKEGC EAIVDTGTSL
     MVGPVDEVRE LQKAIGAVPL IQGEYMIPCE KVSTLPAITL KLGGKGYKLS PEDYTLKAQG
     PGQCPAPLGD PASTTDGAQE ARVPLDGAFW IPRPPAGSPK GCFACVSKPP ALQAPAAPAP
     EPSASPPMAP TLFPMESKSS KTDSVRAAGA PPACKHLAEK KTMTNPTTVI EVYPDTTEVN
     DYYLWSIFNF VYLNFCCLGF IALAYSLKVR DKKLLNDLNG AVEDAKTARL FNITSSALAA
     SCIILVFIFL RYPLTDY
//