ID   A0A1B0GU47_HUMAN        Unreviewed;       540 AA.
AC   A0A1B0GU47;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   05-DEC-2018, entry version 12.
DE   SubName: Full=CUB domain-containing protein 2 {ECO:0000313|Ensembl:ENSP00000489959};
GN   Name=CDCP2 {ECO:0000313|Ensembl:ENSP00000489959};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489959, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000489959, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000489959}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AL357673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENST00000530059; ENSP00000489959; ENSG00000157211.
DR   HGNC; HGNC:27297; CDCP2.
DR   OpenTargets; ENSG00000157211; -.
DR   GeneTree; ENSGT00940000158291; -.
DR   ChiTaRS; CDCP2; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   ExpressionAtlas; A0A1B0GU47; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00041; CUB; 3.
DR   Gene3D; 2.60.120.290; -; 3.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   InterPro; IPR001507; ZP_dom.
DR   Pfam; PF00431; CUB; 3.
DR   Pfam; PF00100; Zona_pellucida; 1.
DR   SMART; SM00042; CUB; 3.
DR   SUPFAM; SSF49854; SSF49854; 3.
DR   PROSITE; PS01180; CUB; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01008102};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    540       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408646.
FT   TRANSMEM    517    539       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       30    143       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      145    255       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      257    373       CUB. {ECO:0000259|PROSITE:PS01180}.
SQ   SEQUENCE   540 AA;  59057 MW;  C44ECD0AEAA9F45C CRC64;
     MLAEWGACLL LAVALLGPGL QAQAMEGVKC GGVLSAPSGN FSSPNFPRLY PYNTECSWLI
     VVAEGSSVLL TFHAFDLEYH DTCSFDFLEI YNGASPDKGN LLGRFCGKVP PPPFTSSWHV
     MSVIFHSDKH VASHGFSAGY QKDVCGGVLT GLSGVLTSPE YPNNYPNSME CHWVIRAAGP
     AHVKLVFVDF QVEGNEECTY DYVAVLGGPG PTRGHHYCGS TRPPTLVSLG HELQVVFKSD
     FNIGGRGFKA YYFSGECQEV YMAMRGNFSS PQYPSSYPNN IRCHWTIRLP PGYQVKVFFL
     DLDLEEPNSL TKTCDFDHLA AFDGASEEAP LLGNWCGHHL PPPVTSSHNQ LLLLLHTDRS
     TTRRGFSVAY IGVVPMNVSC SRTDFQILIS TQALAPLERT KVYLGSRSCA AQEVGGNLRI
     QARFDTCGTE SQRRNNTSVI VSVLYIDFSA AGREDIHEYE VRCEPRRKEA SVHLLSGSHW
     LGPYAATAEH LQEAPPMDEA EALEGPVSMV AQDTSDIVFL GLCILAGILM VIAIVVLMLL
//