ID   A0A1B0GTI9_HUMAN        Unreviewed;       339 AA.
AC   A0A1B0GTI9;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   07-NOV-2018, entry version 10.
DE   SubName: Full=UPF0450 protein C17orf58 {ECO:0000313|Ensembl:ENSP00000489720};
GN   Name=C17orf58 {ECO:0000313|Ensembl:ENSP00000489720};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489720, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000489720, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000489720}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00562025}.
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DR   EMBL; AC134407; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A0A1B0GTI9; -.
DR   Ensembl; ENST00000580729; ENSP00000489720; ENSG00000186665.
DR   HGNC; HGNC:27568; C17orf58.
DR   OpenTargets; ENSG00000186665; -.
DR   GeneTree; ENSGT00390000002361; -.
DR   OMA; FCESEFA; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   ExpressionAtlas; A0A1B0GTI9; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   SUPFAM; SSF50242; SSF50242; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00507203};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A1B0GTI9,
KW   ECO:0000213|PeptideAtlas:A0A1B0GTI9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00507222};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    339       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008408612.
FT   DOMAIN      193    338       NTR. {ECO:0000259|PROSITE:PS50189}.
SQ   SEQUENCE   339 AA;  36985 MW;  42CF85F8625D3D0B CRC64;
     MTARAFWLLC LIVGSSPEAP VAERKTSPPH SRKPDSRGCP SAEETPGPRA QPLLEAPQRP
     RAAEVAPAAR AWPDPRRRKP PPPADNQASF REAARAPAGP PGPRLAQAEN RASPRREPAS
     EDAPRRARSR ALRFPAARPP ALATEGSAGH AHPNRPRAAA LAPGPAPAPP PRFSLSFGLS
     PPQRDAEPGA EPCARACRSD LDEREAFCES EFAVNGIVHD VDVLGAGIRL VTLLVDRDGL
     YKMNRLYLTP DGFFFRVHML ALDSSSCNKP CPEFKPGSRY IVMGHIYHKR RQLPTALLQV
     LRGRLRPGDG LLRSSSSYVK RFNRKREGQI QGAIHTQCI
//