ID   A0A182DWE9_HUMAN        Unreviewed;       258 AA.
AC   A0A182DWE9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   07-NOV-2018, entry version 23.
DE   SubName: Full=HLA class II histocompatibility antigen, DP beta 1 chain {ECO:0000313|Ensembl:ENSP00000372582};
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:SIT60377.1};
GN   Name=HLA-DPB1 {ECO:0000313|EMBL:SIT60377.1,
GN   ECO:0000313|Ensembl:ENSP00000372582};
GN   Synonyms=DPB1 {ECO:0000313|EMBL:SUQ66040.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372582, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000372582, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000372582}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:SIT60377.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Song W.-J., Kurnit D.M.;
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:SIT60377.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Lang K., Schoefl G., Schmidt A., Lange V.;
RT   "Complementing the HLA-DPB1 Database: Full-Length Gene
RT   Characterization of all Common and Well-Documented Alleles.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:SJK83243.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:SUQ66040.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Quirk P.G., Krulwich T.A.;
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|SAAS:SAAS00552561}.
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DR   EMBL; AL662824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LT707878; SIT60377.1; -; Genomic_DNA.
DR   EMBL; LT707879; SIT60378.1; -; Genomic_DNA.
DR   EMBL; LT707880; SIT60379.1; -; Genomic_DNA.
DR   EMBL; LT707881; SIT60380.1; -; Genomic_DNA.
DR   EMBL; LT707882; SIT60381.1; -; Genomic_DNA.
DR   EMBL; LT707883; SIT60382.1; -; Genomic_DNA.
DR   EMBL; LT718928; SJK83243.1; -; Genomic_DNA.
DR   EMBL; LT718929; SJK83244.1; -; Genomic_DNA.
DR   EMBL; LT718930; SJK83245.1; -; Genomic_DNA.
DR   EMBL; LT718931; SJK83246.1; -; Genomic_DNA.
DR   EMBL; LT718963; SJK83278.1; -; Genomic_DNA.
DR   EMBL; LS990940; SUQ66040.1; -; Genomic_DNA.
DR   Ensembl; ENST00000383102; ENSP00000372582; ENSG00000230708.
DR   HGNC; HGNC:4940; HLA-DPB1.
DR   PhylomeDB; A0A182DWE9; -.
DR   ChiTaRS; HLA-DPB1; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.10.320.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   ProDom; PD000328; MHC_II_b_N; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF54452; SSF54452; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00465899};
KW   Immunity {ECO:0000256|SAAS:SAAS00437896};
KW   Membrane {ECO:0000256|SAAS:SAAS00437953, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|SAAS:SAAS00437896};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A182DWE9,
KW   ECO:0000213|PeptideAtlas:A0A182DWE9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00437953,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00437953,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    258       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5015052676.
FT   TRANSMEM    227    246       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      124    212       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   258 AA;  29357 MW;  8BAB349E25A0FFA2 CRC64;
     MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYVYQL RQECYAFNGT QRFLERYIYN
     REEFVRFDSD VGEFRAVTEL GRPDEDYWNS QKDLLEEKRA VPDRVCRHNY ELDEAVTLQR
     RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW
     TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC
     GVGIFMHRRS KKVQRGSA
//