ID   A0A140TA60_HUMAN        Unreviewed;       545 AA.
AC   A0A140TA60;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   05-DEC-2018, entry version 12.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   Name=CES5A {ECO:0000313|Ensembl:ENSP00000458678};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458678};
RN   [1] {ECO:0000313|Ensembl:ENSP00000458678, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000458678}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|RuleBase:RU361235, ECO:0000256|SAAS:SAAS00580646}.
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DR   EMBL; AC007335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020766; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ESTHER; human-CES5A; Carb_B_Chordata.
DR   PeptideAtlas; A0A140TA60; -.
DR   Ensembl; ENST00000573522; ENSP00000458678; ENSG00000261972.
DR   HGNC; HGNC:26459; CES5A.
DR   Proteomes; UP000005640; Chromosome 16.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   Pfam; PF00135; COesterase; 2.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|RuleBase:RU361235,
KW   ECO:0000256|SAAS:SAAS00427783};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A140TA60};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU361235}.
FT   SIGNAL        1     20       {ECO:0000256|RuleBase:RU361235}.
FT   CHAIN        21    545       Carboxylic ester hydrolase.
FT                                {ECO:0000256|RuleBase:RU361235}.
FT                                /FTId=PRO_5007230480.
FT   DOMAIN       31     99       COesterase. {ECO:0000259|Pfam:PF00135}.
FT   DOMAIN      108    509       COesterase. {ECO:0000259|Pfam:PF00135}.
SQ   SEQUENCE   545 AA;  60652 MW;  78B0436154F4D27A CRC64;
     MSGNWVHPGQ ILIWAIWVLA APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV
     PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV LVWFPGGAFK
     TGSASIFDGS ALAAYEDVLV VVVQYRLGIF GFFTTWDQHA PGNWAFKDQV AALSWVQKNI
     EFFGGDPSSV TIFGESAGAI SVSSLILSPM AKGLFHKAIM ESGVAIIPYL EAHDYEKSED
     LQVVAHFCGN NASDSEALLR CLRTKPSKEL LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK
     AFKAIPSIIG VNNHECGFLL PMKEAPEILS GSNKSLALHL IQNILHIPPQ YLHLVANEYF
     HDKHSLTEIR DSLLDLLGDV FFVVPALITA RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV
     KADHADEVRF VFGGAFLKGD IVMFEGATEE EKLLSRKMMK YWATFARTGN PNGNDLSLWP
     AYNLTEQYLQ LDLNMSLGQR LKEPRVEFWT STIPLILSAS DMLHSPLSSL TFLSLLQPFF
     FFCAP
//