ID   A0A140T9Z0_HUMAN        Unreviewed;       693 AA.
AC   A0A140T9Z0;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   16-JAN-2019, entry version 18.
DE   SubName: Full=UDP-glucuronosyltransferase 2A1 {ECO:0000313|Ensembl:ENSP00000425497};
GN   Name=UGT2A1 {ECO:0000313|Ensembl:ENSP00000425497};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000425497};
RN   [1] {ECO:0000313|Ensembl:ENSP00000425497, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000425497}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC       {ECO:0000256|SAAS:SAAS00846206}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC093829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001239203.2; NM_001252274.2.
DR   UniGene; Hs.225950; -.
DR   jPOST; A0A140T9Z0; -.
DR   PeptideAtlas; A0A140T9Z0; -.
DR   PRIDE; A0A140T9Z0; -.
DR   Ensembl; ENST00000514019; ENSP00000425497; ENSG00000173610.
DR   GeneID; 10941; -.
DR   CTD; 10941; -.
DR   HGNC; HGNC:12542; UGT2A1.
DR   OpenTargets; ENSG00000173610; -.
DR   GeneTree; ENSGT00940000161344; -.
DR   OMA; KSVYIYW; -.
DR   OrthoDB; 508327at2759; -.
DR   GenomeRNAi; 10941; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   ExpressionAtlas; A0A140T9Z0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016758; F:transferase activity, transferring hexosyl groups; IEA:InterPro.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   InterPro; IPR035595; UDP_glycos_trans_CS.
DR   Pfam; PF00201; UDPGT; 2.
DR   PROSITE; PS00375; UDPGT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00966082};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    693       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007305497.
FT   TRANSMEM    657    680       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      520    563       UDPGT. {ECO:0000259|PROSITE:PS00375}.
SQ   SEQUENCE   693 AA;  79063 MW;  99A2A6FABC31A089 CRC64;
     MLNNLLLFSL QISLIGTTLG GNVLIWPMEG SHWLNVKIII DELIKKEHNV TVLVASGALF
     ITPTSNPSLT FEIYKVPFGK ERIEGVIKDF VLTWLENRPS PSTIWRFYQE MAKVIKDFHM
     VSQEICDGVL KNQQLMAKLK KSKFEVLVSD PVFPCGDIVA LKLGIPFMYS LRFSPASTVE
     KHCGKVPYPP SYVPAVLSEL TDQMSFTDRI RNFISYHLQD YMFETLWKSW DSYYSKALDG
     SHWLNIKIIL EELIQRNHNV TVLASSATLF INSNPDSPVN FEVIPVSYKK SNIDSLIEHM
     IMLWIDHRPT PLTIWAFYKE LGKLLDTFFQ INIQLCDGVL KNPKLMARLQ KGGFDVLVAD
     PVTICGDLVA LKLGIPFMYT LRFSPASTVE RHCGKIPAPV SYVPAALSEL TDQMTFGERI
     KNTISYSLQD YIFQSYWGEW NSYYSKILGR PTTLCETMGK AEIWLIRTYW DFEFPRPYLP
     NFEFVGGLHC KPAKPLPKVL WRYKGKKPAT LGNNTQLFDW IPQNDLLGHP KTKAFITHGG
     TNGIYEAIYH GVPMVGVPMF ADQPDNIAHM KAKGAAVEVN LNTMTSVDLL SALRTVINEP
     SYKENAMRLS RIHHDQPVKP LDRAVFWIEF VMRHKGAKHL RVAAHDLTWF QYHSLDVIGF
     LLVCVTTAIF LVIQCCLFSC QKFGKIGKKK KRE
//