ID   A0A140T9S4_HUMAN        Unreviewed;       899 AA.
AC   A0A140T9S4;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   16-JAN-2019, entry version 16.
DE   SubName: Full=Gamma-aminobutyric acid type B receptor subunit 1 {ECO:0000313|Ensembl:ENSP00000412044};
GN   Name=GABBR1 {ECO:0000313|Ensembl:ENSP00000412044};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412044};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412044, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000412044}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; BX927223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR388210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A140T9S4; -.
DR   jPOST; A0A140T9S4; -.
DR   PeptideAtlas; A0A140T9S4; -.
DR   Ensembl; ENST00000440316; ENSP00000412044; ENSG00000237051.
DR   HGNC; HGNC:4070; GABBR1.
DR   PhylomeDB; A0A140T9S4; -.
DR   ChiTaRS; GABBR1; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR   CDD; cd15291; 7tmC_GABA-B-R1; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR002455; GPCR3_GABA-B.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   PANTHER; PTHR10519; PTHR10519; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   SUPFAM; SSF57535; SSF57535; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00425515, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A140T9S4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00425515,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    899       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007305470.
FT   TRANSMEM    529    554       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    566    585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    605    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    646    669       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    706    726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    770    792       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      536    814       G_PROTEIN_RECEP_F3_4.
FT                                {ECO:0000259|PROSITE:PS50259}.
FT   COILED      819    860       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   899 AA;  101571 MW;  5497C6E11FA427EF CRC64;
     MLLLLLLAPL FLRPPGAGGV QTPNATSEGC QIIHPPWEGG IRYRGLTRDQ VKAINFLPVD
     YEIEYVCRGE REVVGPKVRK CLANGSWTDM DTPSRCVNRT PHSERRAVYI GALFPMSGGW
     PGGQACQPAV EMALEDVNSR RDILPDYELK LIHHDSKCDP GQATKYLYEL LYNDPIKIIL
     MPGCSSVSTL VAEAARMWNL IVLSYGSSSP ALSNRQRFPT FFRTHPSATL HNPTRVKLFE
     KWGWKKIATI QQTTEVFTST LDDLEERVKE AGIEITFRQS FFSDPAVPVK NLKRQDARII
     VGLFYETEAR KVFCEVYKER LFGKKYVWFL IGWYADNWFK IYDPSINCTV DEMTEAVEGH
     ITTEIVMLNP ANTRSISNMT SQEFVEKLTK RLKRHPEETG GFQEAPLAYD AIWALALALN
     KTSGGGGRSG VRLEDFNYNN QTITDQIYRA MNSSSFEGVS GHVVFDASGS RMAWTLIEQL
     QGGSYKKIGY YDSTKDDLSW SKTDKWIGGS PPADQTLVIK TFRFLSQKLF ISVSVLSSLG
     IVLAVVCLSF NIYNSHVRYI QNSQPNLNNL TAVGCSLALA AVFPLGLDGY HIGRNQFPFV
     CQARLWLLGL GFSLGYGSMF TKIWWVHTVF TKKEEKKEWR KTLEPWKLYA TVGLLVGMDV
     LTLAIWQIVD PLHRTIETFA KEEPKEDIDV SILPQLEHCS SRKMNTWLGI FYGYKGLLLL
     LGIFLAYETK SVSTEKINDH RAVGMAIYNV AVLCLITAPV TMILSSQQDA AFAFASLAIV
     FSSYITLVVL FVPKMRRLIT RGEWQSEAQD TMKTGSSTNN NEEEKSRLLE KENRELEKII
     AEKEERVSEL RHQLQSRQQL RSRRHPPTPP EPSGGLPRGP PEPPDRLSCD GSRVHLLYK
//