ID A0A140T9R5_HUMAN Unreviewed; 2005 AA. AC A0A140T9R5; A0A1U9X969; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 16-JAN-2019, entry version 22. DE SubName: Full=NOTCH4 {ECO:0000313|EMBL:AQY77323.2}; DE SubName: Full=Neurogenic locus notch homolog protein 4 {ECO:0000313|Ensembl:ENSP00000410674}; GN Name=NOTCH4 {ECO:0000313|Ensembl:ENSP00000410674}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000410674}; RN [1] {ECO:0000313|Ensembl:ENSP00000410674, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000410674} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [3] {ECO:0000313|EMBL:AQY77323.2} RP NUCLEOTIDE SEQUENCE. RA Norman P.J., Norberg S.J., Nemat-Gorgani N., Ronaghi M., Parham P.; RT "CDS alleles of MHC region genes derived from homozygous RT individuals."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662830; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KY500855; AQY77323.2; -; Genomic_DNA. DR UniGene; Hs.436100; -. DR ProteinModelPortal; A0A140T9R5; -. DR jPOST; A0A140T9R5; -. DR Ensembl; ENST00000437843; ENSP00000410674; ENSG00000235396. DR HGNC; HGNC:7884; NOTCH4. DR PhylomeDB; A0A140T9R5; -. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd00204; ANK; 2. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR008297; Notch. DR InterPro; IPR035993; Notch-like_dom_sf. DR InterPro; IPR022355; Notch_4. DR InterPro; IPR000800; Notch_dom. DR InterPro; IPR010660; Notch_NOD_dom. DR InterPro; IPR011656; Notch_NODP_dom. DR Pfam; PF00023; Ank; 1. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF00008; EGF; 12. DR Pfam; PF07645; EGF_CA; 5. DR Pfam; PF12661; hEGF; 3. DR Pfam; PF06816; NOD; 1. DR Pfam; PF07684; NODP; 1. DR Pfam; PF00066; Notch; 3. DR PIRSF; PIRSF002279; Notch; 5. DR PRINTS; PR01452; LNOTCHREPEAT. DR PRINTS; PR01987; NOTCH4. DR SMART; SM00248; ANK; 5. DR SMART; SM00181; EGF; 29. DR SMART; SM00179; EGF_CA; 22. DR SMART; SM00004; NL; 3. DR SMART; SM01338; NOD; 1. DR SMART; SM01339; NODP; 1. DR SUPFAM; SSF48403; SSF48403; 1. DR SUPFAM; SSF57184; SSF57184; 5. DR SUPFAM; SSF90193; SSF90193; 2. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 5. DR PROSITE; PS00010; ASX_HYDROXYL; 11. DR PROSITE; PS00022; EGF_1; 27. DR PROSITE; PS01186; EGF_2; 20. DR PROSITE; PS50026; EGF_3; 28. DR PROSITE; PS01187; EGF_CA; 3. DR PROSITE; PS50258; LNR; 3. PE 1: Evidence at protein level; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Calcium {ECO:0000256|PIRSR:PIRSR002279-1}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE- KW ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T9R5, KW ECO:0000213|PeptideAtlas:A0A140T9R5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 2005 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014531359. FT DOMAIN 26 65 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 66 117 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 120 157 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 158 194 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 196 234 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 236 276 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 278 314 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 316 355 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 357 393 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 394 432 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 434 475 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 477 513 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 515 551 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 553 589 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 591 627 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 628 661 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 693 729 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 731 767 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 769 805 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 808 844 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 846 882 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 895 930 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 932 968 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 970 1006 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1008 1046 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1048 1087 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1089 1128 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1132 1173 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1172 1215 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1216 1252 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1253 1296 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1588 1825 ANK_REP_REGION. FT {ECO:0000259|PROSITE:PS50297}. FT REPEAT 1635 1667 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1668 1690 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1702 1734 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1735 1767 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1768 1800 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT METAL 457 457 Calcium 1; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 460 460 Calcium 1; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 477 477 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 480 480 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 494 494 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 516 516 Calcium 3; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 518 518 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 532 532 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT DISULFID 55 64 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 107 116 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 147 156 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 184 193 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 224 233 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 266 275 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 304 313 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 345 354 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 383 392 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 403 420 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 422 431 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 438 454 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 448 463 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 465 474 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 481 492 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 486 501 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 503 512 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 519 530 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 524 539 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 541 550 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 579 588 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 617 626 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 719 728 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 757 766 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 795 804 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 834 843 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 872 881 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 899 909 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 920 929 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 958 967 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 996 1005 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1017 1034 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1036 1045 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1077 1086 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1118 1127 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1163 1172 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 2005 AA; 209818 MW; BC8ED5919D4F74D5 CRC64; MQPPSLLLLL LLLLLLLLCV SVVRPRGLLC GSFPEPCANG GTCLSLSLGQ GTCQCAPGFL GETCQFPDPC QNAQLCQNGG SCQALLPAPL GLPSSPSPLT PSFLCTCLPG FTGERCQAQL EDPCPPSFCS KRGRCHIQAS GRPQCSCMPG WTGEQCQLRD FCSANPCVNG GVCLATYPQI QCHCPPGFEG HACERDVNEC FQDPGPCPKG TSCHNTLGSF QCLCPVGQEG PRCELRAGPC PPRGCSNGGT CQLMPEKDST FHLCLCPPGF IGPDCEVNPD NCVSHQCQNG GTCQDGLDTY TCLCPETWTG WDCSEDVDEC EAQGPPHCRN GGTCQNSAGS FHCVCVSGWG GTSCEENLDD CIAATCAPGS TCIDRVGSFS CLCPPGRTGL LCHLEDMCLS QPCHGDAQCS TNPLTGSTLC LCQPGYSGPT CHQDLDECLM AQQGPSPCEH GGSCLNTPGS FNCLCPPGYT GSRCEADHNE CLSQPCHPGS TCLDLLATFH CLCPPGLEGQ LCEVETNECA SAPCLNHADC HDLLNGFQCI CLPGFSGTRC EEDIDECRSS PCANGGQCQD QPGAFHCKCL PGFEGPRCQT EVDECLSDPC PVGASCLDLP GAFFCLCPSG FTGQLCEVPL CAPNLCQPKQ ICKDQKDKAN CLCPDGSPGC APPEDNCTCH HGHCQRSSCV CDVGWTGPEC EAELGGCISA PCAHGGTCYP QPSGYNCTCP TGYTGPTCSE EMTACHSGPC LNGGSCNPSP GGYYCTCPPS HTGPQCQTST DYCVSAPCFN GGTCVNRPGT FSCLCAMGFQ GPRCEGKLRP SCADSPCRNR ATCQDSPQGP RCLCPTGYTG GSCQTLMDLC AQKPCPRNSH CLQTGPSFHC LCLQGWTGPL CNLPLSSCQK AALSQGIDVS SLCHNGGLCV DSGPSYFCHC PPGFQGSLCQ DHVNPCESRP CQNGATCMAQ PSGYLCQCAP GYDGQNCSKE LDACQSQPCH NHGTCTPKPG GFHCACPPGF VGLRCEGDVD ECLDQPCHPT GTAACHSLAN AFYCQCLPGH TGQWCEVEID PCHSQPCFHG GTCEATAGSP LGFICHCPKG FEGPTCSHRA PSCGFHHCHH GGLCLPSPKP GFPPRCACLS GYGGPDCLTP PAPKGCGPPS PCLYNGSCSE TTGLGGPGFR CSCPHSSPGP RCQKPGAKGC EGRSGDGACD AGCSGPGGNW DGGDCSLGVP DPWKGCPSHS RCWLLFRDGQ CHPQCDSEEC LFDGYDCETP PACTPAYDQY CHDHFHNGHC EKGCNTAECG WDGGDCRPED GDPEWGPSLA LLVVLSPPAL DQQLFALARV LSLTLRVGLW VRKDRDGRDM VYPYPGARAE EKLGGTRDPT YQERAAPQTQ PLGKETDSLS AGFVVVMGVD LSRCGPDHPA SRCPWDPGLL LRFLAAMAAV GALEPLLPGP LLAVHPHAGT APPANQLPWP VLCSPVAGVI LLALGALLVL QLIRRRRREH GALWLPPGFT RRPRTQSAPH RRRPPLGEDS IGLKALKPKA EVDEDGVVMC SGPEEGEEVG QAEETGPPST CQLWSLSGGC GALPQAAMLT PPQESEMEAP DLDTRGPDGV TPLMSAVCCG EVQSGTFQGA WLGCPEPWEP LLDGGACPQA HTVGTGETPL HLAARFSRPT AARRLLEAGA NPNQPDRAGR TPLHAAVAAD AREVCQLLLR SRQTAVDART EDGTTPLMLA ARLAVEDLVE ELIAAQADVG ARDKWGKTAL HWAAAVNNAR AARSLLQAGA DKDAQDNREQ TPLFLAAREG AVEVAQLLLG LGAARELRDQ AGLAPADVAH QRNHWDLLTL LEGAGPPEAR HKATPGREAG PFPRARTVSV SVPPHGGGAL PRCRTLSAGA GPRGGGACLQ ARTWSVDLAA RGGGAYSHCR SLSGVGAGGG PTPRGRRFSA GMRGPRPNPA IMRGRYGVAA GRGGRVSTDD WPCDWVALGA CGSASNIPIP PPCLTPSPER GSPQLDCGPP ALQEMPINQG GEGKK //