ID A0A140T956_HUMAN Unreviewed; 2280 AA. AC A0A140T956; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 16-JAN-2019, entry version 19. DE SubName: Full=Tenascin-X {ECO:0000313|Ensembl:ENSP00000393091}; DE Flags: Fragment; GN Name=TNXB {ECO:0000313|Ensembl:ENSP00000393091}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000393091}; RN [1] {ECO:0000313|Ensembl:ENSP00000393091, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000393091} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR547132; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A140T956; -. DR PeptideAtlas; A0A140T956; -. DR Ensembl; ENST00000451159; ENSP00000393091; ENSG00000236221. DR HGNC; HGNC:11976; TNXB. DR PhylomeDB; A0A140T956; -. DR ChiTaRS; TNXB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0030199; P:collagen fibril organization; IEA:InterPro. DR CDD; cd00063; FN3; 14. DR Gene3D; 2.60.40.10; -; 14. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033081; TNX. DR PANTHER; PTHR19143:SF244; PTHR19143:SF244; 14. DR Pfam; PF07974; EGF_2; 2. DR Pfam; PF00041; fn3; 14. DR SMART; SM00181; EGF; 18. DR SMART; SM00060; FN3; 15. DR SUPFAM; SSF49265; SSF49265; 13. DR PROSITE; PS00022; EGF_1; 6. DR PROSITE; PS01186; EGF_2; 6. DR PROSITE; PS50026; EGF_3; 8. DR PROSITE; PS50853; FN3; 15. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T956, KW ECO:0000213|PeptideAtlas:A0A140T956}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 2280 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305357. FT DOMAIN 214 245 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 276 307 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 338 369 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 400 431 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 462 493 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 524 555 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 617 648 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 715 746 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 751 841 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 842 932 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 959 1051 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1064 1153 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1161 1249 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1263 1352 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1374 1468 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1476 1566 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1574 1669 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1674 1764 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1778 1868 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1883 1971 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1989 2082 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2097 2185 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2196 2280 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT COILED 100 120 {ECO:0000256|SAM:Coils}. FT DISULFID 218 228 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 235 244 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 280 290 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 297 306 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 342 352 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 359 368 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 404 414 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 421 430 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 466 476 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 483 492 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 528 538 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 545 554 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 621 631 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 638 647 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 719 729 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 736 745 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT NON_TER 2280 2280 {ECO:0000313|Ensembl:ENSP00000393091}. SQ SEQUENCE 2280 AA; 245161 MW; 4B4E25A77066AA94 CRC64; MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEEVP TIEGMRMHLL EETTVRTEWT PAPGPVDAYE IQFIPTTEGA SPPFTARVPS SASAYDQRGL APGQEYQVTV RALRGTSWGL PASKTITTMI DGPQDLRVVA VTPTTLELGW LRPQAEVDRF VVSYVSAGNQ RVRLEVPPEA DGTLLTDLMP GVEYVVTVTA ERGRAVSYPA SVRANTGSSP LGLLGTTDEP PPSGPSTTQG AQAPLLQQRP QELGELRVLG RDETGRLRVV WTAQPDTFAY FQLRMRVPEG PGAHEEVLPG DVRQALVPPP PPGTPYELSL HGVPPGGKPS DPIIYQGIMD KDEEKPGKSS GPPRLGELTV TDRTSDSLLL RWTVPEGEFD SFVIQYKDRD GQPQVVPVEG PQRSAVITSL DPGRKYKFVL YGFVGKKRHG PLVAEAKILP QSDPSPGTPP HLGNLWVTDP TPDSLHLSWT VPEGQFDTFM VQYRDRDGRP QVVPVEGPER SFVVSSLDPD HKYRFTLFGI ANKKRYGPLT ADGTTAPERK EEPPRPEFLE QPLLGELTVT GVTPDSLRLS WTVAQGPFDS FMVQYKDAQG QPQAVPVAGD ENEVTVPGLD PDRKYKMNLY GLRGRQRVGP ESVVAKTAPQ EDVDETPSPT ELGTEAPESP EEPLLGELTV TGSSPDSLSL FWTVPQGSFD SFTVQYKDRD GRPRAVRVGG KESEVTVGGL EPGHKYKMHL YGLHEGQRVG PVSAVGVTAP QQEETPPATE SPLEPRLGEL TVTDVTPNSV GLSWTVPEGQ FDSFIVQYKD KDGQPQVVPV AADQREVTVY NLEPERKYKM NMYGLHDGQR MGPLSVVIVT APLPPAPATE ASKPPLEPRL GELTVTDITP DSVGLSWTVP EGEFDSFVVQ YKDRDGQPQV VPVAADQREV TIPDLEPSRK YKFLLFGIQD GKRRSPVSVE AKTVARGDAS PGAPPRLGEL WVTDPTPDSL RLSWTVPEGQ FDSFVVQFKD KDGPQVVPVE GHERSVTVTP LDAGRKYRFL LYGLLGKKRH GPLTADGTTE ARSAMDDTGT KRPPKPRLGE ELQVTTVTQN SVGLSWTVPE GQFDSFVVQY KDRDGQPQVV PVEGSLREVS VPGLDPAHRY KLLLYGLHHG KRVGPISAVA ITAGREETET ETTAPTPPAP EPHLGELTVE EATSHTLHLS WMVTEGEFDS FEIQYTDRDG QLQMVRIGGD RNDITLSGLE SDHRYLVTLY GFSDGKHVGP VHVEALTVPE EEKPSEPPTA TPEPPIKPRL GELTVTDATP DSLSLSWTVP EGQFDHFLVQ YRNGDGQPKA VRVPGHEEGV TISGLEPDHK YKMNLYGFHG GQRMGPVSVV GVTAAEEETP SPTEPSMEAP EPAEEPLLGE LTVTGSSPDS LSLSWTVPQG RFDSFTVQYK DRDGRPQVVR VGGEESEVTV GGLEPGRKYK MHLYGLHEGR RVGPVSAVGV TAPEEESPDA PLAKLRLGQM TVRDITSDSL SLSWTVPEGQ FDHFLVQFKN GDGQPKAVRV PGHEDGVTIS GLEPDHKYKM NLYGFHGGQR VGPVSAVGLT //