ID A0A140T902_HUMAN Unreviewed; 4222 AA. AC A0A140T902; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 16-JAN-2019, entry version 21. DE SubName: Full=Tenascin-X {ECO:0000313|Ensembl:ENSP00000387561}; GN Name=TNXB {ECO:0000313|Ensembl:ENSP00000387561}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000387561}; RN [1] {ECO:0000313|Ensembl:ENSP00000387561, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000387561} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; CR753803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753845; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A140T902; -. DR PeptideAtlas; A0A140T902; -. DR Ensembl; ENST00000440248; ENSP00000387561; ENSG00000231608. DR HGNC; HGNC:11976; TNXB. DR PhylomeDB; A0A140T902; -. DR ChiTaRS; TNXB; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0030199; P:collagen fibril organization; IEA:InterPro. DR CDD; cd00063; FN3; 31. DR CDD; cd00087; FReD; 1. DR Gene3D; 2.60.40.10; -; 31. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR036056; Fibrinogen-like_C. DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom. DR InterPro; IPR020837; Fibrinogen_CS. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033081; TNX. DR PANTHER; PTHR19143:SF244; PTHR19143:SF244; 21. DR Pfam; PF07974; EGF_2; 2. DR Pfam; PF00147; Fibrinogen_C; 1. DR Pfam; PF00041; fn3; 31. DR SMART; SM00181; EGF; 18. DR SMART; SM00186; FBG; 1. DR SMART; SM00060; FN3; 32. DR SUPFAM; SSF49265; SSF49265; 29. DR SUPFAM; SSF56496; SSF56496; 1. DR PROSITE; PS00022; EGF_1; 6. DR PROSITE; PS01186; EGF_2; 6. DR PROSITE; PS50026; EGF_3; 8. DR PROSITE; PS00514; FIBRINOGEN_C_1; 1. DR PROSITE; PS51406; FIBRINOGEN_C_2; 1. DR PROSITE; PS50853; FN3; 32. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00730685}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T902, KW ECO:0000213|PeptideAtlas:A0A140T902}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 4222 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5007305400. FT DOMAIN 214 245 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 276 307 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 338 369 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 400 431 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 462 493 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 524 555 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 617 648 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 715 746 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 751 841 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 842 932 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 959 1051 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1064 1153 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1161 1249 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1263 1352 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1374 1468 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1476 1566 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1574 1669 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1674 1764 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1778 1868 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1883 1971 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1989 2082 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2097 2185 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2196 2286 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2305 2398 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2408 2502 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2519 2617 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2625 2723 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2733 2830 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2835 2928 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2938 3035 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3040 3131 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3146 3238 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3242 3333 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3335 3424 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3429 3522 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3531 3625 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3635 3732 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3736 3825 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3826 3912 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3913 4003 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 3999 4214 Fibrinogen C-terminal. FT {ECO:0000259|PROSITE:PS51406}. FT COILED 100 120 {ECO:0000256|SAM:Coils}. FT DISULFID 218 228 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 235 244 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 280 290 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 297 306 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 342 352 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 359 368 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 404 414 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 421 430 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 466 476 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 483 492 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 528 538 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 545 554 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 621 631 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 638 647 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 719 729 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 736 745 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 4222 AA; 456160 MW; CE5277F33A46F355 CRC64; MMPAQYALTS SLVLLVLLST ARAGPFSSRS NVTLPAPRPP PQPGGHTVGA GVGSPSSQLY EHTVEGGEKQ VVFTHRINLP PSTGCGCPPG TEPPVLASEV QALRVRLEIL EELVKGLKEQ CTGGCCPASA QAGTGQTDVR TLCSLHGVFD LSRCTCSCEP GWGGPTCSDP TDAEIPPSSP PSASGSCPDD CNDQGRCVRG RCVCFPGYTG PSCGWPSCPG DCQGRGRCVQ GVCVCRAGFS GPDCSQRSCP RGCSQRGRCE GGRCVCDPGY TGDDCGMRSC PRGCSQRGRC ENGRCVCNPG YTGEDCGVRS CPRGCSQRGR CKDGRCVCDP GYTGEDCGTR SCPWDCGEGG RCVDGRCVCW PGYTGEDCST RTCPRDCRGR GRCEDGECIC DTGYSGDDCG VRSCPGDCNQ RGRCEDGRCV CWPGYTGTDC GSRACPRDCR GRGRCENGVC VCNAGYSGED CGVRSCPGDC RGRGRCESGR CMCWPGYTGR DCGTRACPGD CRGRGRCVDG RCVCNPGFTG EDCGSRRCPG DCRGHGLCED GVCVCDAGYS GEDCSTRSCP GGCRGRGQCL DGRCVCEDGY SGEDCGVRQC PNDCSQHGVC QDGVCICWEG YVSEDCSIRT CPSNCHGRGR CEEGRCLCDP GYTGPTCATR MCPADCRGRG RCVQGVCLCH VGYGGEDCGQ EEPPASACPG GCGPRELCRA GQCVCVEGFR GPDCAIQTCP GDCRGRGECH DGSCVCKDGY AGEDCGEEVP TIEGMRMHLL EETTVRTEWT PAPGPVDAYE IQFIPTTEGA SPPFTARVPS SASAYDQRGL APGQEYQVTV RALRGTSWGL PASKTITTMI DGPQDLRVVA VTPTTLELGW LRPQAEVDRF VVSYVSAGNQ RVRLEVPPEA DGTLLTDLMP GVEYVVTVTA ERGRAVSYPA SVRANTGSSP LGLLGTTDEP PPSGPSTTQG AQAPLLQQRP QELGELRVLG RDETGRLRVV WTAQPDTFAY FQLRMRVPEG PGAHEEVLPG DVRQALVPPP PPGTPYELSL HGVPPGGKPS DPIIYQGIMD KDEEKPGKSS GPPRLGELTV TDRTSDSLLL RWTVPEGEFD SFVIQYKDRD GQPQVVPVEG PQRSAVITSL DPGRKYKFVL YGFVGKKRHG PLVAEAKILP QSDPSPGTPP RLGNLWVTDP TPDSLHLSWT VPEGQFDTFM VQYRDRDGRP QVVPVEGPER SFVVSSLDPD HKYRFTLFGI ANKKRYGPLT ADGTTAPERK EEPPHPEFLE QPLLGELTVT GVTPDSLRLS WTVAQGPFDS FMVQYKDAQG QPQAVPVAGD ENEVTVPGLD PDRKYKMNLY GLRGRQRVGP ESVVAKTAPQ EDVDETPSPT ELGTEAPESP EEPLLGELTV TGSSPDSLSL FWTVPQGSFD SFTVQYKDRD GRPRAVRVGG KESEVTVGGL EPGHKYKMHL YGLHEGQRVG PVSAVGVTAP QQEETPPATE SPLEPRLGEL TVTDVTPNSV GLSWTVPEGQ FDSFIVQYKD KDGQPQVVPV AADQREVTVY NLEPERKYKM NMYGLHDGQR MGPLSVVIVT APLPPAPATE ASKPPLEPRL GELTVTDITP DSVGLSWTVP EGEFDSFVVQ YKDRDGQPQV VPVAADQREV TIPDLEPSRK YKFLLFGIQD GKRRSPVSVE AKTVARGDAS PGAPPRLGEL WVTDPTPDSL RLSWTVPEGQ FDSFVVQFKD KDGPQVVPVE GHERSVTVTP LDAGRKYRFL LYGLLGKKRH GPLTADGTTE ARSAMDDTGT KRPPKPRLGE ELQVTTVTQN SVGLSWTVPE GQFDSFVVQY KDRDGQPQVV PVEGSLREVS VPGLDPAHRY KLLLYGLHHG KRVGPISAVA ITAGREETET ETTAPTPPAP EPHLGELTVE EATSHTLHLS WMVTEGEFDS FEIQYTDRDG QLQMVRIGGD RNDITLSGLE SDHRYLVTLY GFSDGKHVGP VHVEALTVPE EEKPSEPPTA TPEPPIKPRL GELTVTDATP DSLSLSWTVP EGQFDHFLVQ YRNGDGQPKA VRVPGHEEGV TISGLEPDHK YKMNLYGFHG GQRMGPVSVV GVTAAEEETP SPTEPSMEAP EPAEEPLLGE LTVTGSSPDS LSLSWTVPQG RFDSFTVQYK DRDGRPQVVR VGGEESEVTV GGLEPGRKYK MHLYGLHEGR RVGPVSAVGV TAPEEESPDA PLAKLRLGQM TVRDITSDSL SLSWTVPEGQ FDHFLVQFKN GDGQPKAVRV PGHEDGVTIS GLEPDHKYKM NLYGFHGGQR VGPVSAVGLT APGKDEEMAP ASTEPPTPEP PIKPRLEELT VTDATPDSLS LSWTVPEGQF DHFLVQYKNG DGQPKATRVP GHEDRVTISG LEPDNKYKMN LYGFHGGQRV GPVSAIGVTA AEEETPSPTE PSMEAPEPPE EPLLGELTVT GSSPDSLSLS WTVPQGRFDS FTVQYKDRDG RPQVVRVGGE ESEVTVGGLE PGRKYKMHLY GLHEGRRVGP VSTVGVTAPQ EDVDETPSPT EPGTEAPEPP EEPLLGELTV TGSSPDSLSL SWTVPQGRFD SFTVQYKDRD GRPQAVRVGG QESKVTVRGL EPGRKYKMHL YGLHEGRRLG PVSAVGVTED EAETTQAVPT MTPEPPIKPR LGELTMTDAT PDSLSLSWTV PEGQFDHFLV QYRNGDGQPK AVRVPGHEDG VTISGLEPDH KYKMNLYGFH GGQRVGPISV IGVTAAEEET PSPTELSTEA PEPPEEPLLG ELTVTGSSPD SLSLSWTIPQ GHFDSFTVQY KDRDGRPQVM RVRGEESEVT VGGLEPGRKY KMHLYGLHEG RRVGPVSTVG VTVPTTTPEP PNKPRLGELT VTDATPDSLS LSWMVPEGQF DHFLVQYRNG DGQPKVVRVP GHEDGVTISG LEPDHKYKMN LYGFHGGQRV GPISVIGVTA AEEETPAPTE PSTEAPEPPE EPLLGELTVT GSSPDSLSLS WTIPQGRFDS FTVQYKDRDG RPQVVRVRGE ESEVTVGGLE PGCKYKMHLY GLHEGQRVGP VSAVGVTVPT MTPEPPIKPR LGELTVTDAT PDSLSLSWMV PEGQFDHFLV QYRNGDGQPK AVRVPGHEDG VTISGLEPDH KYKMNLYGFH GGQRVGPVSA IGVTEEETPS PTEPSTEAPE APEEPLLGEL TVTGSSPDSL SLSWTIPQGR FDSFTVQYKD RDGQPQVVRV RGEESEVTVG GLEPGRKYKM HLYGLHEGQR VGPVSTVGIT APLPTPLPVE PRLGELAVAA VTSDSVGLSW TVAQGPFDSF LVQYRDAQGQ PQAVPVSGDL RAVAVSGLDP ARKYKFLLFG LQNGKRHGPV PVEARTAPDT KPSPRLGELT VTDATPDSVG LSWTVPEGEF DSFVVQYKDK DGRLQVVPVA ANQREVTVQG LEPSRKYRFL LYGLSGRKRL GPISADSTTA PLEKELPPHL GELTVAEETS SSLRLSWTVA QGPFDSFVVQ YRDTDGQPRA VPVAADQRTV TVEDLEPGKK YKFLLYGLLG GKRLGPVSAL GMTAPEEDTP APELAPEAPE PPEEPRLGVL TVTDTTPDSM RLSWSVAQGP FDSFVVQYED TNGQPQALLV DGDQSKILIS GLEPSTPYRF LLYGLHEGKR LGPLSAEGTT GLAPAGQTSE ESRPRLSQLS VTDVTTSSLR LNWEAPPGAF DSFLLRFGVP SPSTLEPHPR PLLQRELMVP GTRHSAVLRD LRSGTLYSLT LYGLRGPHKA DSIQGTARTL SPVLESPRDL QFSEIRETSA KVNWMPPPSR ADSFKVSYQL ADGGEPQSVQ VDGQARTQKL QGLIPGARYE VTVVSVRGFE ESEPLTGFLT TVPDGPTQLR ALNLTEGFAV LHWKPPQNPV DTYDIQVTAP GAPPLQAETP GSAVDYPLHD LVLHTNYTAT VRGLRGPNLT SPASITFTTG LEAPRDLEAK EVTPRTALLT WTEPPVRPAG YLLSFHTPGG QTQEILLPGG ITSHQLLGLF PSTSYNARLQ ATWGQSLLPP VSTSFTTGGL RIPFPRDCGE EMQNGAGASR TSTIFLNGNR ERPLNVFCDM ETDGGGWLVF QRRMDGQTDF WRDWEDYAHG FGNISGEFWL GNEALHSLTQ AGDYSMRVDL RAGDEAVFAQ YDSFHVDSAA EYYRLHLEGY HGTAGDSMSY HSGSVFSARD RDPNSLLISC AVSYRGAWWY RNCHYANLNG LYGSTVDHQG VSWYHWKGFE FSVPFTEMKL RPRNFRSPAG GG //