ID A0A140T8Y6_HUMAN Unreviewed; 2003 AA. AC A0A140T8Y6; A0A1U9X973; DT 11-MAY-2016, integrated into UniProtKB/TrEMBL. DT 11-MAY-2016, sequence version 1. DT 16-JAN-2019, entry version 21. DE SubName: Full=NOTCH4 {ECO:0000313|EMBL:AQY77338.2}; DE SubName: Full=Neurogenic locus notch homolog protein 4 {ECO:0000313|Ensembl:ENSP00000372751}; GN Name=NOTCH4 {ECO:0000313|Ensembl:ENSP00000372751}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000372751}; RN [1] {ECO:0000313|Ensembl:ENSP00000372751, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000372751} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. RN [3] {ECO:0000313|EMBL:AQY77338.2} RP NUCLEOTIDE SEQUENCE. RA Norman P.J., Norberg S.J., Nemat-Gorgani N., Ronaghi M., Parham P.; RT "CDS alleles of MHC region genes derived from homozygous RT individuals."; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL845464; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL845509; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KY500870; AQY77338.2; -; Genomic_DNA. DR UniGene; Hs.436100; -. DR ProteinModelPortal; A0A140T8Y6; -. DR jPOST; A0A140T8Y6; -. DR Ensembl; ENST00000383264; ENSP00000372751; ENSG00000206312. DR HGNC; HGNC:7884; NOTCH4. DR PhylomeDB; A0A140T8Y6; -. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:InterPro. DR GO; GO:0007275; P:multicellular organism development; IEA:InterPro. DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro. DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro. DR CDD; cd00204; ANK; 2. DR Gene3D; 1.25.40.20; -; 1. DR InterPro; IPR002110; Ankyrin_rpt. DR InterPro; IPR020683; Ankyrin_rpt-contain_dom. DR InterPro; IPR036770; Ankyrin_rpt-contain_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR008297; Notch. DR InterPro; IPR035993; Notch-like_dom_sf. DR InterPro; IPR022355; Notch_4. DR InterPro; IPR000800; Notch_dom. DR InterPro; IPR010660; Notch_NOD_dom. DR InterPro; IPR011656; Notch_NODP_dom. DR Pfam; PF00023; Ank; 1. DR Pfam; PF12796; Ank_2; 1. DR Pfam; PF00008; EGF; 11. DR Pfam; PF07645; EGF_CA; 5. DR Pfam; PF12661; hEGF; 4. DR Pfam; PF06816; NOD; 1. DR Pfam; PF07684; NODP; 1. DR Pfam; PF00066; Notch; 3. DR PIRSF; PIRSF002279; Notch; 5. DR PRINTS; PR01452; LNOTCHREPEAT. DR PRINTS; PR01987; NOTCH4. DR SMART; SM00248; ANK; 5. DR SMART; SM00181; EGF; 29. DR SMART; SM00179; EGF_CA; 22. DR SMART; SM00004; NL; 3. DR SMART; SM01338; NOD; 1. DR SMART; SM01339; NODP; 1. DR SUPFAM; SSF48403; SSF48403; 1. DR SUPFAM; SSF57184; SSF57184; 3. DR SUPFAM; SSF90193; SSF90193; 2. DR PROSITE; PS50297; ANK_REP_REGION; 1. DR PROSITE; PS50088; ANK_REPEAT; 5. DR PROSITE; PS00010; ASX_HYDROXYL; 11. DR PROSITE; PS00022; EGF_1; 26. DR PROSITE; PS01186; EGF_2; 19. DR PROSITE; PS50026; EGF_3; 28. DR PROSITE; PS01187; EGF_CA; 3. DR PROSITE; PS50258; LNR; 3. PE 1: Evidence at protein level; KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}; KW Calcium {ECO:0000256|PIRSR:PIRSR002279-1}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002279-2, ECO:0000256|PROSITE- KW ProRule:PRU00076, ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00032677}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1}; KW Proteomics identification {ECO:0000213|MaxQB:A0A140T8Y6, KW ECO:0000213|PeptideAtlas:A0A140T8Y6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 23 {ECO:0000256|SAM:SignalP}. FT CHAIN 24 2003 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014531356. FT DOMAIN 24 63 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 64 115 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 118 155 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 156 192 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 194 232 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 234 274 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 276 312 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 314 353 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 355 391 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 392 430 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 432 473 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 475 511 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 513 549 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 551 587 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 589 625 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 626 659 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 691 727 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 729 765 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 767 803 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 806 842 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 844 880 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 893 928 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 930 966 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 968 1004 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1006 1044 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1046 1085 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1087 1126 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1130 1171 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1170 1213 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1214 1250 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1251 1294 LNR. {ECO:0000259|PROSITE:PS50258}. FT DOMAIN 1586 1823 ANK_REP_REGION. FT {ECO:0000259|PROSITE:PS50297}. FT REPEAT 1633 1665 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1666 1688 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1700 1732 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1733 1765 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT REPEAT 1766 1798 ANK. {ECO:0000256|PROSITE- FT ProRule:PRU00023}. FT METAL 455 455 Calcium 1; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 458 458 Calcium 1; via amide nitrogen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 475 475 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 478 478 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 492 492 Calcium 2. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 514 514 Calcium 3; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 516 516 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT METAL 530 530 Calcium 3. FT {ECO:0000256|PIRSR:PIRSR002279-1}. FT DISULFID 53 62 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 105 114 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 145 154 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 182 191 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 222 231 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 264 273 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 302 311 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 343 352 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 381 390 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 401 418 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 420 429 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 436 452 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 446 461 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 463 472 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 479 490 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 484 499 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 501 510 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 517 528 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 522 537 {ECO:0000256|PIRSR:PIRSR002279-2}. FT DISULFID 539 548 {ECO:0000256|PIRSR:PIRSR002279-2, FT ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 577 586 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 615 624 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 717 726 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 755 764 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 793 802 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 832 841 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 870 879 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 897 907 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 918 927 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 956 965 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 994 1003 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1015 1032 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1034 1043 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1075 1084 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1116 1125 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 1161 1170 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 2003 AA; 209664 MW; AF697FAD1355A614 CRC64; MQPPSLLLLL LLLLLLCVSV VRPRGLLCGS FPEPCANGGT CLSLSLGQGT CQCAPGFLGE TCQFPDPCQN AQLCQNGGSC QALLPAPLGL PSSPSPLTPS FLCTCLPGFT GERCQAKLED PCPPSFCSKR GRCHIQASGR PQCSCMPGWT GEQCQLRDFC SANPCVNGGV CLATYPQIQC HCPPGFEGHA CERDVNECFQ DPGPCPKGTS CHNTLGSFQC LCPVGQEGPR CELRAGPCPP RGCSNGGTCQ LMPEKDSTFH LCLCPPGFIG PDCEVNPDNC VSHQCQNGGT CQDGLDTYTC LCPETWTGWD CSEDVDECET QGPPHCRNGG TCQNSAGSFH CVCVSGWGGT SCEENLDDCI AATCAPGSTC IDRVGSFSCL CPPGRTGLLC HLEDMCLSQP CHGDAQCSTN PLTGSTLCLC QPGYSGPTCH QDLDECLMAQ QGPSPCEHGG SCLNTPGSFN CLCPPGYTGS RCEADHNECL SQPCHPGSTC LDLLATFHCL CPPGLEGQLC EVETNECASA PCLNHADCHD LLNGFQCICL PGFSGTRCEE DIDECRSSPC ANGGQCQDQP GAFHCKCLPG FEGPRCQTEV DECLSDPCPV GASCLDLPGA FFCLCPSGFT GQLCEVPLCA PNLCQPKQIC KDQKDKANCL CPDGSPGCAP PEDNCTCHHG HCQRSSCVCD VGWTGPECEA ELGGCISAPC AHGGTCYPQP SGYNCTCPTG YTGPTCSEEM TACHSGPCLN GGSCNPSPGG YYCTCPPSHT GPQCQTSTDY CVSAPCFNGG TCVNRPGTFS CLCAMGFQGP RCEGKLRPSC ADSPCRNRAT CQDSPQGPRC LCPTVYTGGS CQTLMDLCAQ KPCPRNSHCL QTGPSFHCLC LQGWTGPLCN LPLSSCQKAA LSQGIDVSSL CHNGGLCVDS GPSYFCHCPP GFQGSLCQDH VNPCESRPCQ NGATCMAQPS GYLCQCAPGY DGQNCSKELD ACQSQPCHNH GTCTPKPGGF HCACPPGFVG LRCEGDVDEC LDQPCHPTGT AACHSLANAF YCQCLPGHTG QWCEVEIDPC HSQPCFHGGT CEATAGSPLG FICHCPKGFE GPTCSHRAPS CGFHHCHHGG LCLPSPKPGF PPRCACLSGY GGPDCLTPPA PKGCGPPSPC LYNGSCSETT GLGGPGFRCS CPHSSPGPRC QKPGAKGCEG RSGDGACDAG CSGPGGNWDG GDCSLGVPDP WKGCPSHSRC WLLFRDGQCH PQCDSEECLF DGYDCETPPA CTPAYDQYCH DHFHNGHCEK GCNTAECGWD GGDCRPEDGD PEWGPSLALL VVLSPPALDQ QLFALARVLS LTLRVGLWVR KDRDGRDMVY PYPGARAEEK LGGTRDPTYQ ERAAPQTQPL GKETDSLSAG FVVVMGVDLS RCGPDHPASR CPWDPGLLLR FLAAMAAVGA LEPLLPGPLL AVHPHAGTAP PANQLPWPVL CSPVAGVILL ALGALLVLQL IRRRRREHGA LWLPPGFTRR PRTQSAPHRR RPPLGEDSIG LKALKPKAEV DEDGVVMCSG PEEGEEVGQA EETGPPSTCQ LWSLSGGCGA LPQAAMLTPP QESEMEAPDL DTRGPDGVTP LMSAVCCGEV QSGTFQGAWL GCPEPWEPLL DGGACPQAHT VGTGETPLHL AARFSRPTAA RRLLEAGANP NQPDRAGRTP LHAAVAADAR EVCQLLLRSR QTAVDARTED GTTPLMLAAR LAVEDLVEEL IAAQADVGAR DKWGKTALHW AAAVNNARAA RSLLQAGADK DAQDNREQTP LFLAAREGAV EVAQLLLGLG AARELRDQAG LAPADVAHQR NHWDLLTLLE GAGPPEARHK ATPGREAGPF PRARTVSVSV PPHGGGALPR CRTLSAGAGP RGGGACLQAR TWSVDLAARG GGAYSHCRSL SGVGAGGGPT PRGRRFSAGM RGPRPNPAIM RGRYGVAAGR GGRVSTDDWP CDWVALGACG SASNIPIPPP CLTPSPERGS PQLDCGPPAL QEMPINQGGE GKK //