ID   A0A140T8X8_HUMAN        Unreviewed;       626 AA.
AC   A0A140T8X8;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   16-JAN-2019, entry version 20.
DE   SubName: Full=Mucin-21 {ECO:0000313|Ensembl:ENSP00000373027};
GN   Name=MUC21 {ECO:0000313|Ensembl:ENSP00000373027};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000373027};
RN   [1] {ECO:0000313|Ensembl:ENSP00000373027, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000373027}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2016) to UniProtKB.
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DR   EMBL; AL773541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001309300.1; NM_001322371.1.
DR   UniGene; Hs.448277; -.
DR   BioMuta; ENSG00000206463; -.
DR   jPOST; A0A140T8X8; -.
DR   Ensembl; ENST00000383535; ENSP00000373027; ENSG00000206463.
DR   GeneID; 394263; -.
DR   CTD; 394263; -.
DR   OrthoDB; 1589631at2759; -.
DR   ChiTaRS; MUC21; human.
DR   GenomeRNAi; 394263; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022408; P:negative regulation of cell-cell adhesion; IBA:GO_Central.
DR   InterPro; IPR033534; MUC21.
DR   InterPro; IPR028199; Mucin_dom.
DR   InterPro; IPR008519; Tandem-repeating_mucin.
DR   PANTHER; PTHR39408; PTHR39408; 2.
DR   Pfam; PF14654; Epiglycanin_C; 1.
DR   Pfam; PF05647; Epiglycanin_TR; 10.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    626       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5007305390.
FT   TRANSMEM    540    562       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20     83       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN       77    134       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      109    165       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      154    210       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      197    257       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      257    316       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      305    362       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      362    420       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      409    460       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      453    518       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      524    622       Epiglycanin_C.
FT                                {ECO:0000259|Pfam:PF14654}.
SQ   SEQUENCE   626 AA;  59868 MW;  2FBA84BB83FE30A8 CRC64;
     MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA
     TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTASS GISIATNSES STTSSGASTA
     TNSESSTPSS GASTVTNSGS SVTSSGASTA TNSESSTVSS RASTATNSES STLSSGASTA
     TNSDSSTTSS GASTATNSES STTSSGASTA TNSESSTVSS RASTATNSES STTSSGASTA
     TNSESRTTSN GAGTATNSES STTSSGASTA TNSDSSTVSS GASTATNSES STTSSGASTA
     TNSDSSTTSS GAGTATNSES STTSSGASTA TNSESSTTSS GASTATNSDS STTSSGAGTA
     TNSESSTVSS GISTVTNSES STPSSGANTA TNSESSTTSS GANTATNSES STVSSGASTA
     TNSESSTTSS GVSTATNSES STTSSGASTA TNSDSSTTSS EASTATNSES STVSSGISTV
     TNSESSTTSS GANTATNSGS SVTSAGSGTA ALTGMHTTSH SASTAVSEAK PGGSLVPWEI
     FLITLVSVVA AVGLFAGLFF CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP
     RWSPNWFWRR PVSSIAMEMS GRNSGP
//