ID   A0A126GVR6_HUMAN        Unreviewed;       329 AA.
AC   A0A126GVR6;
DT   11-MAY-2016, integrated into UniProtKB/TrEMBL.
DT   11-MAY-2016, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN   Name=OR4C3 {ECO:0000313|EMBL:ALI87519.1,
GN   ECO:0000313|Ensembl:ENSP00000493096};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ALI87519.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000493096, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|EMBL:ALI87519.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mainland J.D., Li Y.R., Zhou T., Liu W.L.L., Matsunami H.;
RT   "Human Olfactory Receptor Responses to Odorants.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000493096}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363047, ECO:0000256|SAAS:SAAS00857205};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047,
CC       ECO:0000256|SAAS:SAAS00857205}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00857212}.
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DR   EMBL; AC023080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KP290343; ALI87519.1; -; Genomic_DNA.
DR   RefSeq; NP_001004702.1; NM_001004702.1.
DR   UniGene; Hs.553656; -.
DR   ProteinModelPortal; A0A126GVR6; -.
DR   Ensembl; ENST00000641889; ENSP00000493096; ENSG00000176547.
DR   GeneID; 256144; -.
DR   KEGG; hsa:256144; -.
DR   CTD; 256144; -.
DR   HGNC; HGNC:14697; OR4C3.
DR   GeneTree; ENSGT00940000163173; -.
DR   KO; K04257; -.
DR   OMA; RTISYEC; -.
DR   OrthoDB; 947735at2759; -.
DR   PhylomeDB; A0A126GVR6; -.
DR   GenomeRNAi; 256144; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   ExpressionAtlas; A0A126GVR6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857207};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857203};
KW   Membrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857194, ECO:0000256|SAAS:SAAS00857207};
KW   Olfaction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857209};
KW   Receptor {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Sensory transduction {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857209}; Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|RuleBase:RU000688,
KW   ECO:0000256|SAAS:SAAS00857203};
KW   Transmembrane {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857194};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363047,
KW   ECO:0000256|SAAS:SAAS00857194}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    329       Olfactory receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014041219.
FT   TRANSMEM     51     72       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM     84    103       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    123    145       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    165    191       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    218    250       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    262    284       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   TRANSMEM    296    314       Helical. {ECO:0000256|RuleBase:RU363047}.
FT   DOMAIN       66    312       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   329 AA;  36677 MW;  E30BFEFDC3B9DE70 CRC64;
     MQLVLLLMFL LVFIGNTAPA FSVTLESMDI PQNITEFFML GLSQNSEVQR VLFVVFLLIY
     VVTVCGNMLI VVTITSSPTL ASPVYFFLAN LSFIDTFYSS SMAPKLIADS LYEGRTISYE
     CCMAQLFGAH FLGGVEIILL TVMAYDRYVA ICKPLHNTTI MTRHLCAMLV GVAWLGGFLH
     SLVQLLLVLW LPFCGPNVIN HFACDLYPLL EVACTNTYVI GLLVVANSGL ICLLNFLMLA
     ASYIVILYSL RSHSADGRCK ALSTCGAHFI VVALFFVPCI FTYVHPFSTL PIDKNMALFY
     GILTPMLNPL IYTLRNEEVK NAMRKLFTW
//