ID   A0A0U1RR20_HUMAN        Unreviewed;      1361 AA.
AC   A0A0U1RR20;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   16-JAN-2019, entry version 27.
DE   SubName: Full=Proteoglycan 4 {ECO:0000313|Ensembl:ENSP00000489292};
GN   Name=PRG4 {ECO:0000313|Ensembl:ENSP00000489292};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489292};
RN   [1] {ECO:0000313|Ensembl:ENSP00000489292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000213|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
RA   Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
RA   Blagoev B.;
RT   "System-wide temporal characterization of the proteome and
RT   phosphoproteome of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:rs3-RS3(2011).
RN   [4] {ECO:0000313|Ensembl:ENSP00000489292}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2015) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL133553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001290161.1; NM_001303232.1.
DR   UniGene; Hs.647723; -.
DR   SMR; A0A0U1RR20; -.
DR   jPOST; A0A0U1RR20; -.
DR   PRIDE; A0A0U1RR20; -.
DR   Ensembl; ENST00000635041; ENSP00000489292; ENSG00000116690.
DR   GeneID; 10216; -.
DR   CTD; 10216; -.
DR   HGNC; HGNC:9364; PRG4.
DR   OpenTargets; ENSG00000116690; -.
DR   OrthoDB; 419397at2759; -.
DR   ChiTaRS; PRG4; human.
DR   GenomeRNAi; 10216; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   ExpressionAtlas; A0A0U1RR20; baseline and differential.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd00094; HX; 1.
DR   Gene3D; 2.110.10.10; -; 1.
DR   InterPro; IPR000585; Hemopexin-like_dom.
DR   InterPro; IPR036375; Hemopexin-like_dom_sf.
DR   InterPro; IPR018487; Hemopexin-like_repeat.
DR   InterPro; IPR018486; Hemopexin_CS.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR020436; Somatomedin_B_chordata.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   Pfam; PF00045; Hemopexin; 1.
DR   Pfam; PF01033; Somatomedin_B; 2.
DR   PRINTS; PR00022; SOMATOMEDINB.
DR   SMART; SM00120; HX; 2.
DR   SMART; SM00201; SO; 2.
DR   SUPFAM; SSF50923; SSF50923; 1.
DR   SUPFAM; SSF90188; SSF90188; 2.
DR   PROSITE; PS00024; HEMOPEXIN; 1.
DR   PROSITE; PS51642; HEMOPEXIN_2; 2.
DR   PROSITE; PS00524; SMB_1; 2.
DR   PROSITE; PS50958; SMB_2; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00734812};
KW   Proteomics identification {ECO:0000213|EPD:A0A0U1RR20,
KW   ECO:0000213|MaxQB:A0A0U1RR20, ECO:0000213|PeptideAtlas:A0A0U1RR20};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00878391};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1361       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5006714357.
FT   DOMAIN       26     69       SMB. {ECO:0000259|PROSITE:PS50958}.
FT   DOMAIN       70    108       SMB. {ECO:0000259|PROSITE:PS50958}.
FT   REPEAT     1105   1148       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
FT   REPEAT     1149   1196       Hemopexin. {ECO:0000256|PROSITE-
FT                                ProRule:PRU01011}.
SQ   SEQUENCE   1361 AA;  146452 MW;  75109738F5EED204 CRC64;
     MAWKTLPIYL LLLLSVFVIQ QVSSQDLSSC AGRCGEGYSR DATCNCDYNC QHYMECCPDF
     KRVCTAELSC KGRCFESFER GRECDCDAQC KKYDKCCPDY ESFCAEVHNP TSPPSSKKAP
     PPSGASQTIK STTKRSPKPP NKKKTKKVIE SEEITEVKDN KKNRTKKKPT PKPPVVDEAG
     SGLDNGDFKV TTPDTSTTQH NKVSTSPKIT TAKPINPRPS LPPNSDTSKE TSLTVNKETT
     VETKETTTTN KQTSTDGKEK TTSAKETQSI EKTSAKDLAP TSKVLAKPTP KAETTTKGPA
     LTTPKEPTPT TPKEPASTTP KEPTPTTIKS APTTPKEPAP TTTKSAPTTP KEPAPTTTKE
     PAPTTPKEPA PTTTKEPAPT TTKSAPTTPK EPAPTTPKKP APTTPKEPAP TTPKEPTPTT
     PKEPAPTTKE PAPTTPKEPA PTAPKKPAPT TPKEPAPTTP KEPAPTTTKE PSPTTPKEPA
     PTTTKSAPTT TKEPAPTTTK SAPTTPKEPS PTTTKEPAPT TPKEPAPTTP KKPAPTTPKE
     PAPTTPKEPA PTTTKKPAPT TPKEPAPTTP KETAPTTPKK LTPTTPEKLA PTTPEKPAPT
     TPEELAPTTP EEPTPTTPEE PAPTTPKAAA PNTPKEPAPT TPKEPAPTTP KEPAPTTPKE
     TAPTTPKGTA PTTLKEPAPT TPKKPAPKEL APTTTKEPTS TTSDKPAPTT PKGTAPTTPK
     EPAPTTPKEP APTTPKGTAP TTLKEPAPTT PKKPAPKELA PTTTKGPTST TSDKPAPTTP
     KETAPTTPKE PAPTTPKKPA PTTPETPPPT TSEVSTPTTT KEPTTIHKSP DESTPELSAE
     PTPKALENSP KEPGVPTTKT PAATKPEMTT TAKDKTTERD LRTTPETTTA APKMTKETAT
     TTEKTTESKI TATTTQVTST TTQDTTPFKI TTLKTTTLAP KVTTTKKTIT TTEIMNKPEE
     TAKPKDRATN SKATTPKPQK PTKAPKKPTS TKKPKTMPRV RKPKTTPTPR KMTSTMPELN
     PTSRIAEAML QTTTRPNQTP NSKLVEVNPK SEDAGGAEGE TPHMLLRPHV FMPEVTPDMD
     YLPRVPNQGI IINPMLSDET NICNGKPVDG LTTLRNGTLV AFRGHYFWML SPFSPPSPAR
     RITEVWGIPS PIDTVFTRCN CEGKTFFFKD SQYWRFTNDI KDAGYPKPIF KGFGGLTGQI
     VAALSTAKYK NWPESVYFFK RGGSIQQYIY KQEPVQKCPG RRPALNYPVY GETTQVRRRR
     FERAIGPSQT HTIRIQYSPA RLAYQDKGVL HNEVKVSILW RGLPNVVTSA ISLPNIRKPD
     GYDYYAFSKD QYYNIDVPSR TARAITTRSG QTLSKVWYNC P
//