ID   A0A0U1RR13_HUMAN        Unreviewed;       264 AA.
AC   A0A0U1RR13;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 2.
DT   23-MAY-2018, entry version 15.
DE   RecName: Full=Phosphatase and actin regulator {ECO:0000256|RuleBase:RU301113};
DE   Flags: Fragment;
GN   Name=PHACTR1 {ECO:0000313|Ensembl:ENSP00000489276};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489276};
RN   [1] {ECO:0000313|Ensembl:ENSP00000489276}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000489276}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2015) to UniProtKB.
CC   -!- SUBUNIT: Binds PPP1CA and actin. {ECO:0000256|RuleBase:RU301113}.
CC   -!- SIMILARITY: Belongs to the phosphatase and actin regulator family.
CC       {ECO:0000256|RuleBase:RU301113}.
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DR   EMBL; AC213202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL391385; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0U1RR13; -.
DR   PeptideAtlas; A0A0U1RR13; -.
DR   Ensembl; ENST00000635715; ENSP00000489276; ENSG00000282833.
DR   HGNC; HGNC:20990; PHACTR1.
DR   ChiTaRS; PHACTR1; human.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008157; F:protein phosphatase 1 binding; IEA:InterPro.
DR   GO; GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:InterPro.
DR   InterPro; IPR029987; Phactr1.
DR   InterPro; IPR004018; RPEL_repeat.
DR   PANTHER; PTHR12751:SF6; PTHR12751:SF6; 1.
DR   Pfam; PF02755; RPEL; 1.
DR   SMART; SM00707; RPEL; 1.
DR   PROSITE; PS51073; RPEL; 1.
PE   1: Evidence at protein level;
KW   Actin-binding {ECO:0000256|RuleBase:RU301113};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0U1RR13};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|RuleBase:RU301113};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    264       Phosphatase and actin regulator.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008234696.
FT   REPEAT      174    199       RPEL. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00401}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000489276}.
FT   NON_TER     264    264       {ECO:0000313|Ensembl:ENSP00000489276}.
SQ   SEQUENCE   264 AA;  29473 MW;  5CF8EDC505769AE2 CRC64;
     XSPFTPFSPL LSFFLSPFFF LFPSLSHSLP TPSLPLPSPF PSPSPVREPL PLPSSPFRLS
     PSPSVSFSLS ARRATLLLPP TLMAASSEDD IDRRPIRRVR SKSDTPYLAE ARISFNLGAA
     EEVERLAAMR SDSLVPGTHT PPIRRRSKFA NLGRIFKPWK WRKKKSEKFK HTSAALERKI
     SMRQSREELI KRGVLKEIYD KDGELSISNE EDSLENGQSL SSSQLSLPAL SEMEPVPMPR
     DPCSYEVLQP SDIMDGPVSE ESPS
//