ID A0A0S2Z4L7_HUMAN Unreviewed; 210 AA. AC A0A0S2Z4L7; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 05-DEC-2018, entry version 13. DE SubName: Full=Toll-like receptor 2 isoform 2 {ECO:0000313|EMBL:ALQ33823.1}; DE Flags: Fragment; GN Name=TLR2 {ECO:0000313|EMBL:ALQ33823.1, GN ECO:0000313|Ensembl:ENSP00000494668}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALQ33823.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000494668, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|EMBL:ALQ33823.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by RT Alternative Splicing."; RL Cell 164:805-817(2016). RN [3] {ECO:0000313|Ensembl:ENSP00000494668} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC106865; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU178365; ALQ33823.1; -; mRNA. DR UniGene; Hs.519033; -. DR PeptideAtlas; A0A0S2Z4L7; -. DR Ensembl; ENST00000643087; ENSP00000494668; ENSG00000137462. DR HGNC; HGNC:11848; TLR2. DR OpenTargets; ENSG00000137462; -. DR GeneTree; ENSGT00940000156323; -. DR Proteomes; UP000005640; Chromosome 4. DR ExpressionAtlas; A0A0S2Z4L7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro. DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro. DR GO; GO:0050707; P:regulation of cytokine secretion; IEA:InterPro. DR GO; GO:0002237; P:response to molecule of bacterial origin; IEA:InterPro. DR GO; GO:0034134; P:toll-like receptor 2 signaling pathway; IEA:InterPro. DR Gene3D; 3.40.50.10140; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR000157; TIR_dom. DR InterPro; IPR027185; TLR2. DR InterPro; IPR035897; Toll_tir_struct_dom_sf. DR PANTHER; PTHR24365:SF17; PTHR24365:SF17; 2. DR Pfam; PF01582; TIR; 1. DR SMART; SM00255; TIR; 1. DR SUPFAM; SSF52200; SSF52200; 1. DR PROSITE; PS51450; LRR; 1. DR PROSITE; PS50104; TIR; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0S2Z4L7, KW ECO:0000213|PeptideAtlas:A0A0S2Z4L7}; KW Receptor {ECO:0000313|EMBL:ALQ33823.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 210 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006608243. FT DOMAIN 66 210 TIR. {ECO:0000259|PROSITE:PS50104}. FT NON_TER 210 210 {ECO:0000313|EMBL:ALQ33823.1, FT ECO:0000313|Ensembl:ENSP00000494668}. SQ SEQUENCE 210 AA; 24292 MW; 85EE14A8A69AAFE3 CRC64; MPHTLWMVWV LGVIISLSKE ESSNQASLSC DRNGICKGSS GSLNSIPSGL TEAVKSLDLS NNRITYISNS DLQSERDAYW VENLMVQELE NFNPPFKLCL HKRDFIPGKW IIDNIIDSIE KSHKTVFVLS ENFVKSEWCK YELDFSHFRL FDENNDAAIL ILLEPIEKKA IPQRFCKLRK IMNTKTYLEW PMDEAQREGF WVNLRAAIKS //