ID A0A0S2Z4L3_HUMAN Unreviewed; 708 AA. AC A0A0S2Z4L3; DT 17-FEB-2016, integrated into UniProtKB/TrEMBL. DT 17-FEB-2016, sequence version 1. DT 13-FEB-2019, entry version 26. DE SubName: Full=Protein S isoform 2 {ECO:0000313|EMBL:ALQ33742.1}; DE SubName: Full=Vitamin K-dependent protein S {ECO:0000313|Ensembl:ENSP00000497376}; DE Flags: Fragment; GN Name=PROS1 {ECO:0000313|EMBL:ALQ33742.1, GN ECO:0000313|Ensembl:ENSP00000497376}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ALQ33742.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000497376, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|EMBL:ALQ33742.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26871637; DOI=10.1016/j.cell.2016.01.029; RA Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T., RA Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K., RA Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q., RA Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D., RA Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J., RA Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P., RA Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.; RT "Widespread Expansion of Protein Interaction Capabilities by RT Alternative Splicing."; RL Cell 164:805-817(2016). RN [4] {ECO:0000313|Ensembl:ENSP00000497376} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2018) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC117474; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC144562; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KU178284; ALQ33742.1; -; mRNA. DR RefSeq; NP_001301006.1; NM_001314077.1. DR UniGene; Hs.64016; -. DR PeptideAtlas; A0A0S2Z4L3; -. DR Ensembl; ENST00000650591; ENSP00000497376; ENSG00000184500. DR GeneID; 5627; -. DR CTD; 5627; -. DR HGNC; HGNC:9456; PROS1. DR OpenTargets; ENSG00000184500; -. DR GeneTree; ENSGT00940000154035; -. DR OrthoDB; 317733at2759; -. DR ChiTaRS; PROS1; human. DR GenomeRNAi; 5627; -. DR Proteomes; UP000005640; Chromosome 3. DR ExpressionAtlas; A0A0S2Z4L3; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0030195; P:negative regulation of blood coagulation; IEA:InterPro. DR Gene3D; 4.10.740.10; -; 1. DR InterPro; IPR017857; Coagulation_fac-like_Gla_dom. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR001881; EGF-like_Ca-bd_dom. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR018097; EGF_Ca-bd_CS. DR InterPro; IPR035972; GLA-like_dom_SF. DR InterPro; IPR000294; GLA_domain. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR033189; PROS1. DR PANTHER; PTHR24040:SF0; PTHR24040:SF0; 1. DR Pfam; PF00008; EGF; 1. DR Pfam; PF07645; EGF_CA; 2. DR Pfam; PF00594; Gla; 1. DR Pfam; PF00054; Laminin_G_1; 1. DR Pfam; PF02210; Laminin_G_2; 1. DR PRINTS; PR00001; GLABLOOD. DR SMART; SM00181; EGF; 4. DR SMART; SM00179; EGF_CA; 4. DR SMART; SM00069; GLA; 1. DR SMART; SM00282; LamG; 2. DR SUPFAM; SSF49899; SSF49899; 2. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF57630; SSF57630; 1. DR PROSITE; PS00010; ASX_HYDROXYL; 4. DR PROSITE; PS00022; EGF_1; 1. DR PROSITE; PS01186; EGF_2; 3. DR PROSITE; PS50026; EGF_3; 4. DR PROSITE; PS01187; EGF_CA; 2. DR PROSITE; PS00011; GLA_1; 1. DR PROSITE; PS50998; GLA_2; 1. DR PROSITE; PS50025; LAM_G_DOMAIN; 2. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00122, KW ECO:0000256|SAAS:SAAS00601599}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076, KW ECO:0000256|SAAS:SAAS00602928}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0S2Z4L3, KW ECO:0000213|PeptideAtlas:A0A0S2Z4L3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00594563}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 708 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006608248. FT DOMAIN 73 119 Gla. {ECO:0000259|PROSITE:PS50998}. FT DOMAIN 149 187 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 189 232 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 233 274 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 275 315 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 331 507 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 516 698 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DISULFID 158 175 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 177 186 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 193 203 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 671 698 {ECO:0000256|PROSITE-ProRule:PRU00122}. FT NON_TER 708 708 {ECO:0000313|EMBL:ALQ33742.1}. SQ SEQUENCE 708 AA; 78854 MW; 7019A63DD3043AB2 CRC64; MRVLGGRCGA LLACLLLVLP VSEANFCLYF RNDFIYNRAC ISVLVGLSGC NFFYSICFLS KQQASQVLVR KRRANSLLEE TKQGNLEREC IEELCNKEEA REVFENDPET DYFYPKYLVC LRSFQTGLFT AARQSTNAYP DLRSCVNAIP DQCSPLPCNE DGYMSCKDGK ASFTCTCKPG WQGEKCEFDI NECKDPSNIN GGCSQICDNT PGSYHCSCKN GFVMLSNKKD CKDVDECSLK PSICGTAVCK NIPGDFECEC PEGYRYNLKS KSCEDIDECS ENMCAQLCVN YPGGYTCYCD GKKGFKLAQD QKSCEVVSVC LPLNLDTKYE LLYLAEQFAG VVLYLKFRLP EISRFSAEFD FRTYDSEGVI LYAESIDHSA WLLIALRGGK IEVQLKNEHT SKITTGGDVI NNGLWNMVSV EELEHSISIK IAKEAVMDIN KPGPLFKPEN GLLETKVYFA GFPRKVESEL IKPINPRLDG CIRSWNLMKQ GASGIKEIIQ EKQNKHCLVT VEKGSYYPGS GIAQFHIDYN NVSSAEGWHV NVTLNIRPST GTGVMLALVS GNNTVPFAVS LVDSTSEKSQ DILLSVENTV IYRIQALSLC SDQQSHLEFR VNRNNLELST PLKIETISHE DLQRQLAVLD KAMKAKVATY LGGLPDVPFS ATPVNAFYNG CMEVNINGVQ LDLDEAISKH NDIRAHSCPS VWKKTKNS //