ID A0A0R4J2G7_HUMAN Unreviewed; 1495 AA. AC A0A0R4J2G7; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 16-JAN-2019, entry version 25. DE SubName: Full=Neurexin-1-beta {ECO:0000313|Ensembl:ENSP00000434015}; GN Name=NRXN1 {ECO:0000313|Ensembl:ENSP00000434015}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434015, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000434015, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000434015} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2015) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007682; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC009234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC010721; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068715; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068725; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC069550; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC078994; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_011531477.1; XM_011533175.2. DR UniGene; Hs.637685; -. DR PeptideAtlas; A0A0R4J2G7; -. DR Ensembl; ENST00000405472; ENSP00000434015; ENSG00000179915. DR GeneID; 9378; -. DR CTD; 9378; -. DR HGNC; HGNC:8008; NRXN1. DR OpenTargets; ENSG00000179915; -. DR GeneTree; ENSGT00940000154292; -. DR OrthoDB; 35129at2759; -. DR ChiTaRS; NRXN1; human. DR GenomeRNAi; 9378; -. DR Proteomes; UP000005640; Chromosome 2. DR ExpressionAtlas; A0A0R4J2G7; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR037440; Neurexin. DR InterPro; IPR003585; Neurexin-like. DR InterPro; IPR027789; Syndecan/Neurexin_dom. DR PANTHER; PTHR44287; PTHR44287; 2. DR Pfam; PF00008; EGF; 1. DR Pfam; PF02210; Laminin_G_2; 6. DR Pfam; PF01034; Syndecan; 1. DR SMART; SM00294; 4.1m; 1. DR SMART; SM00181; EGF; 3. DR SMART; SM00282; LamG; 6. DR SUPFAM; SSF49899; SSF49899; 6. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS50026; EGF_3; 3. DR PROSITE; PS50025; LAM_G_DOMAIN; 6. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00814887}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAAS:SAAS00094946, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4J2G7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00094946, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00094946, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1495 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5006452035. FT TRANSMEM 1421 1441 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 217 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 219 256 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 279 461 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 468 660 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 664 701 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 706 879 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 893 1068 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1071 1108 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1114 1312 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. SQ SEQUENCE 1495 AA; 164255 MW; 6EE9BFECE5A0C91E CRC64; MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKEEYIA TFKGSEYFCY DLSQNPIQSS SDEITLSFKT LQRNGLMLHT GKSADYVNLA LKNGAVSLVI NLGSGAFEAL VEPVNGKFND NAWHDVKVTR NLRQVTISVD GILTTTGYTQ EDYTMLGSDD FFYVGGSPST ADLPGSPVSN NFMGCLKEVV YKNNDVRLEL SRLAKQGDPK MKIHGVVAFK CENVATLDPI TFETPESFIS LPKWNAKKTG SISFDFRTTE PNGLILFSHG KPRHQKDAKH PQMIKVDFFA IEMLDGHLYL LLDMGSGTIK IKALLKKVND GEWYHVDFQR DGRSGTISVN TLRTPYTAPG ESEILDLDDE LYLGGLPENK AGLVFPTEVW TALLNYGYVG CIRDLFIDGQ SKDIRQMAEV QSTAGVKPSC SKETAKPCLS NPCKNNGMCR DGWNRYVCDC SGTGYLGRSC EREATVLSYD GSMFMKIQLP VVMHTEAEDV SLRFRSQRAY GILMATTSRD SADTLRLELD AGRVKLTVNL DCIRINCNSS KGPETLFAGY NLNDNEWHTV RVVRRGKSLK LTVDDQQAMT GQMAGDHTRL EFHNIETGII TERRYLSSVP SNFIGHLQSL TFNGMAYIDL CKNGDIDYCE LNARFGFRNI IADPVTFKTK SSYVALATLQ AYTSMHLFFQ FKTTSLDGLI LYNSGDGNDF IVVELVKGYL HYVFDLGNGA NLIKGSSNKP LNDNQWHNVM ISRDTSNLHT VKIDTKITTQ ITAGARNLDL KSDLYIGGVA KETYKSLPKL VHAKEGFQGC LASVDLNGRL PDLISDALFC NGQIERGCEG PSTTCQEDSC SNQGVCLQQW DGFSCDCSMT SFSGPLCNDP GTTYIFSKGG GQITYKWPPN DRPSTRADRL AIGFSTVQKE AVLVRVDSSS GLGDYLELHI HQGKIGVKFN VGTDDIAIEE SNAIINDGKY HVVRFTRSGG NATLQVDSWP VIERYPAGNN DNERLAIARQ RIPYRLGRVV DEWLLDKGRQ LTIFNSQATI IIGGKEQGQP FQGQLSGLYY NGLKVLNMAA ENDANIAIVG NVRLVGEVPS SMTTESTATA MQSEMSTSIM ETTTTLATST ARRGKPPTKE PISQTTDDIL VASAECPSDD EDIDPCEPSS GGLANPTRAG GREPYPGSAE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS YHVDESRNYI SNSAQSNGAV VKEKQPSSAK SSNKNKKNKD KEYYV //