ID A0A0R4J2F0_HUMAN Unreviewed; 116 AA. AC A0A0R4J2F0; DT 20-JAN-2016, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 1. DT 12-SEP-2018, entry version 14. DE RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|RuleBase:RU362129}; GN Name=CGA {ECO:0000313|Ensembl:ENSP00000358595}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000358595, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000358595, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000358595} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2016) to UniProtKB. CC -!- SUBUNIT: Heterodimer. The active hormones thyrotropin, lutropin CC and follitropin are heterodimers composed of CGA, a common alpha CC chain described here and a unique beta chain which confers their CC biological specificity to the hormones: TSHB for thyrotropin, LHB CC for lutropin and FSHB for follitropin. CC {ECO:0000256|RuleBase:RU362129}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362129, CC ECO:0000256|SAAS:SAAS00521609}. CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha CC family. {ECO:0000256|RuleBase:RU362129, CC ECO:0000256|SAAS:SAAS00594029}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL138827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PeptideAtlas; A0A0R4J2F0; -. DR Ensembl; ENST00000369582; ENSP00000358595; ENSG00000135346. DR HGNC; HGNC:1885; CGA. DR OpenTargets; ENSG00000135346; -. DR GeneTree; ENSGT00390000012242; -. DR ChiTaRS; CGA; human. DR Proteomes; UP000005640; Chromosome 6. DR ExpressionAtlas; A0A0R4J2F0; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR000476; Glyco_hormone. DR PANTHER; PTHR11509; PTHR11509; 1. DR Pfam; PF00236; Hormone_6; 1. DR PRINTS; PR00274; GLYCOHORMONE. DR SMART; SM00067; GHA; 1. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS00779; GLYCO_HORMONE_ALPHA_1; 1. DR PROSITE; PS00780; GLYCO_HORMONE_ALPHA_2; 1. DR PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00521605}; KW Glycoprotein {ECO:0000256|RuleBase:RU362129}; KW Hormone {ECO:0000256|RuleBase:RU362129, KW ECO:0000256|SAAS:SAAS00135161}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0R4J2F0, KW ECO:0000213|PeptideAtlas:A0A0R4J2F0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|RuleBase:RU362129, KW ECO:0000256|SAAS:SAAS00521604}; KW Signal {ECO:0000256|RuleBase:RU362129}. FT SIGNAL 1 22 {ECO:0000256|RuleBase:RU362129}. FT CHAIN 23 116 Glycoprotein hormones alpha chain. FT {ECO:0000256|RuleBase:RU362129}. FT /FTId=PRO_5005967686. SQ SEQUENCE 116 AA; 13233 MW; DF35DDAF92E18DAF CRC64; MQLSFWSHCR CFCMFSIPLL MCRVRDQICD CPECTLQENP FFSQPGAPIL QCMGCCFSRA YPTPLRSKKT MLVQKNVTSE STCCVAKSYN RVTVMGGFKV ENHTACHCST CYYHKS //