ID   CD3CH_HUMAN             Reviewed;         201 AA.
AC   A0A0K2S4Q6; A0A0K2S5L2; A0A286YF48;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   11-NOV-2015, sequence version 1.
DT   13-FEB-2019, entry version 20.
DE   RecName: Full=Protein CD300H {ECO:0000305};
DE   AltName: Full=CD300 antigen-like family member H;
DE   Flags: Precursor;
GN   Name=CD300H {ECO:0000312|HGNC:HGNC:52292};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), POLYMORPHISM, TISSUE
RP   SPECIFICITY, INTERACTION WITH TYROBP AND HCST, SUBCELLULAR LOCATION
RP   (ISOFORM 2), AND FUNCTION.
RX   PubMed=26221034; DOI=10.1074/jbc.M115.643361;
RA   Niizuma K., Tahara-Hanaoka S., Noguchi E., Shibuya A.;
RT   "Identification and Characterization of CD300H, a New Member of the
RT   Human CD300 Immunoreceptor Family.";
RL   J. Biol. Chem. 290:22298-22308(2015).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- FUNCTION: May play an important role in innate immunity by
CC       mediating a signal for the production of a neutrophil
CC       chemoattractant. {ECO:0000269|PubMed:26221034}.
CC   -!- SUBUNIT: Interacts with TYROBP and HCST.
CC       {ECO:0000269|PubMed:26221034}.
CC   -!- SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000255}; Single-
CC       pass type I membrane protein {ECO:0000255}.
CC   -!- SUBCELLULAR LOCATION: Isoform 2: Secreted
CC       {ECO:0000269|PubMed:26221034}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=CD300H {ECO:0000303|PubMed:26221034};
CC         IsoId=A0A0K2S4Q6-1; Sequence=Displayed;
CC       Name=2; Synonyms=CD300Hs {ECO:0000303|PubMed:26221034};
CC         IsoId=A0A0K2S4Q6-2; Sequence=VSP_059910, VSP_059911;
CC   -!- TISSUE SPECIFICITY: Expressed on CD16+ monocytes and myeloid
CC       dendritic cells. By contrast, is not expressed on lymphocytes or
CC       granulocytes. {ECO:0000269|PubMed:26221034}.
CC   -!- POLYMORPHISM: Some individuals have a mutation
CC       (NM_001324073.1:c.61+1A>G) which abolishes the intron 1 donor
CC       splice site. These persons carrying the A/A genotype shows a loss
CC       of CD300H transcripts and protein. The AA genotype occurs at high
CC       frequencies in East Asian and Northern/Western European
CC       populations, but is rare in the Yoruba (West African) population.
CC       {ECO:0000269|PubMed:26221034}.
CC   -!- SIMILARITY: Belongs to the CD300 family. {ECO:0000305}.
CC   -!- CAUTION: The reference genome assembly (GRCh38.p12) represents the
CC       'A' allele (NM_001324073.1:c.61+1A>G) which abolishes the intron 1
CC       donor splice site leading to loss of CD300H transcripts and
CC       protein. {ECO:0000305|PubMed:26221034}.
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DR   EMBL; LC013475; BAS22088.1; -; mRNA.
DR   EMBL; LC013476; BAS22089.1; -; mRNA.
DR   EMBL; AC079325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86635.1; -. [A0A0K2S4Q6-2]
DR   CCDS; CCDS86636.1; -. [A0A0K2S4Q6-1]
DR   RefSeq; NP_001311002.1; NM_001324073.1. [A0A0K2S4Q6-1]
DR   RefSeq; NP_001311005.1; NM_001324076.1. [A0A0K2S4Q6-2]
DR   SMR; A0A0K2S4Q6; -.
DR   BioMuta; ENSG00000284690; -.
DR   Ensembl; ENST00000641031; ENSP00000492997; ENSG00000284690. [A0A0K2S4Q6-2]
DR   Ensembl; ENST00000641710; ENSP00000492977; ENSG00000284690. [A0A0K2S4Q6-1]
DR   GeneID; 100130520; -.
DR   KEGG; hsa:100130520; -.
DR   CTD; 100130520; -.
DR   GeneCards; CD300H; -.
DR   HGNC; HGNC:52292; CD300H.
DR   MIM; 616560; gene.
DR   GeneTree; ENSGT00940000163948; -.
DR   KO; K06719; -.
DR   OrthoDB; 1494510at2759; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   ExpressionAtlas; A0A0K2S4Q6; differential.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001816; P:cytokine production; IDA:UniProtKB.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IDA:UniProtKB.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Membrane; Reference proteome; Secreted; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25    201       Protein CD300H.
FT                                /FTId=PRO_5014029141.
FT   TOPO_DOM     25    168       Extracellular. {ECO:0000255}.
FT   TRANSMEM    169    189       Helical. {ECO:0000255}.
FT   TOPO_DOM    190    201       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       25    123       Ig-like V-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00114}.
FT   CARBOHYD    100    100       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00498}.
FT   DISULFID     43    111       {ECO:0000255|PROSITE-ProRule:PRU00114}.
FT   VAR_SEQ     140    153       ASSTENSVKTPASP -> GPCPAAPASCFSHS (in
FT                                isoform 2).
FT                                {ECO:0000303|PubMed:26221034}.
FT                                /FTId=VSP_059910.
FT   VAR_SEQ     154    201       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:26221034}.
FT                                /FTId=VSP_059911.
SQ   SEQUENCE   201 AA;  21806 MW;  935CF5928B5622DE CRC64;
     MTQRAGAAML PSALLLLCVP GCLTVSGPST VMGAVGESLS VQCRYEEKYK TFNKYWCRQP
     CLPIWHEMVE TGGSEGVVRS DQVIITDHPG DLTFTVTLEN LTADDAGKYR CGIATILQED
     GLSGFLPDPF FQVQVLVSSA SSTENSVKTP ASPTRPSQCQ GSLPSSTCFL LLPLLKVPLL
     LSILGAILWV NRPWRTPWTE S
//