ID   A0A0J9YXG7_HUMAN        Unreviewed;       134 AA.
AC   A0A0J9YXG7;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   16-JAN-2019, entry version 20.
DE   SubName: Full=Glypican-2 {ECO:0000313|Ensembl:ENSP00000488396};
GN   Name=GPC2 {ECO:0000313|Ensembl:ENSP00000488396};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000488396, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000488396, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000488396}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- FUNCTION: Cell surface proteoglycan that bears heparan sulfate.
CC       {ECO:0000256|RuleBase:RU003519}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU003519}; Lipid-anchor, GPI-anchor
CC       {ECO:0000256|RuleBase:RU003519}.
CC   -!- SIMILARITY: Belongs to the glypican family.
CC       {ECO:0000256|RuleBase:RU003518}.
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DR   EMBL; AC073842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0J9YXG7; -.
DR   jPOST; A0A0J9YXG7; -.
DR   PeptideAtlas; A0A0J9YXG7; -.
DR   Ensembl; ENST00000480087; ENSP00000488396; ENSG00000213420.
DR   EuPathDB; HostDB:ENSG00000213420.7; -.
DR   HGNC; HGNC:4450; GPC2.
DR   OpenTargets; ENSG00000213420; -.
DR   GeneTree; ENSGT00940000154015; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000213420; Expressed in 174 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; A0A0J9YXG7; baseline and differential.
DR   GO; GO:0046658; C:anchored component of plasma membrane; IEA:InterPro.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   InterPro; IPR001863; Glypican.
DR   InterPro; IPR031181; Glypican-2.
DR   PANTHER; PTHR10822; PTHR10822; 1.
DR   PANTHER; PTHR10822:SF24; PTHR10822:SF24; 1.
DR   Pfam; PF01153; Glypican; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Glycoprotein {ECO:0000256|RuleBase:RU003519};
KW   GPI-anchor {ECO:0000256|RuleBase:RU003519};
KW   Heparan sulfate {ECO:0000256|RuleBase:RU003519};
KW   Lipoprotein {ECO:0000256|RuleBase:RU003519};
KW   Membrane {ECO:0000256|RuleBase:RU003519};
KW   Proteoglycan {ECO:0000256|RuleBase:RU003519};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0J9YXG7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    134       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005326183.
SQ   SEQUENCE   134 AA;  14358 MW;  08D11CFB849183FA CRC64;
     MSALRPLLLL LLPLCPGPGP GPGSEAKVTR SCAETRQVLG ARGYSLNLIP PALISGEHLR
     VCPQEYTCCS SETEQRLIRE TEATFRGLVE DSGSFLVHTL AARHRKFDDN PDPGGCPSLC
     AGPGDWKKCG QRSA
//