ID   A0A0J9YW40_HUMAN        Unreviewed;      1074 AA.
AC   A0A0J9YW40;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   16-JAN-2019, entry version 18.
DE   SubName: Full=Transmembrane protein 132E {ECO:0000313|Ensembl:ENSP00000487800};
GN   Name=TMEM132E {ECO:0000313|Ensembl:ENSP00000487800};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000487800, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000487800, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000487800}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   EMBL; AC005691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001291367.1; NM_001304438.1.
DR   UniGene; Hs.310482; -.
DR   ProteinModelPortal; A0A0J9YW40; -.
DR   PeptideAtlas; A0A0J9YW40; -.
DR   Ensembl; ENST00000631683; ENSP00000487800; ENSG00000181291.
DR   GeneID; 124842; -.
DR   KEGG; hsa:124842; -.
DR   CTD; 124842; -.
DR   EuPathDB; HostDB:ENSG00000181291.6; -.
DR   HGNC; HGNC:26991; TMEM132E.
DR   OpenTargets; ENSG00000181291; -.
DR   GeneTree; ENSGT00940000158479; -.
DR   KO; K17599; -.
DR   OMA; SLWISYS; -.
DR   OrthoDB; 598074at2759; -.
DR   ChiTaRS; TMEM132E; human.
DR   GenomeRNAi; 124842; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000181291; Expressed in 127 organ(s), highest expression level in right hemisphere of cerebellum.
DR   ExpressionAtlas; A0A0J9YW40; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026307; TMEM132.
DR   InterPro; IPR031436; TMEM132_C.
DR   InterPro; IPR031437; TMEM132_M.
DR   InterPro; IPR031435; TMEM132_N.
DR   PANTHER; PTHR13388; PTHR13388; 1.
DR   Pfam; PF16070; TMEM132; 1.
DR   Pfam; PF15706; TMEM132D_C; 1.
DR   Pfam; PF15705; TMEM132D_N; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0J9YW40};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   1074       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5005326472.
FT   TRANSMEM    889    914       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       45    176       TMEM132D_N. {ECO:0000259|Pfam:PF15705}.
FT   DOMAIN      449    795       TMEM132. {ECO:0000259|Pfam:PF16070}.
FT   DOMAIN      876    941       TMEM132D_C. {ECO:0000259|Pfam:PF15706}.
SQ   SEQUENCE   1074 AA;  116150 MW;  26257CBDD25FE880 CRC64;
     MAPGMSGRGG AALLCLSALL AHASGRSHPA SPSPPGPQAS PVLPVSYRLS HTRLAFFLRE
     ARPPSPAVAN SSLQRSEPFV VFQTKELPVL NVSLGPFSTS QVVARELLQP SSTLDIPERL
     TVNWKVRAFI VRSHVPASQP VVQVLFYVAG RDWDDFGVTE RLPCVRLHAF RDAREVKSSC
     RLSGGLATCL VRAELPLAWF GPPAPAAPPT ARRKSPDGLE PEATGESQQA ELYYTLHAPD
     ASGGCGGSRR GAGPGVGARA ESPTQHPLLR IGSISLFRPP PRRTLQEHRL DSNLMIRLPD
     RPLKPGEVLS ILLYLAPNSS SPSSPSVEHF TLRVKAKKGV TLLGTKSRSG QWHVTSELLT
     GAKHSTATVD VAWAQSTPLP PREGQGPLEI LQLDFEMENF TSQSVKRRIM WHIDYRGHGA
     LPDLERAVTE LTVIQRDVQA ILPLAMDTEI INTAILTGRT VAIPVKVIAI EVNGLVLDIS
     ALVECESDNE DIIKVSSSCD YVFVSGKESR GSMNARVTFR YDVLNAPLEM TVWVPKLPLH
     IELSDARLSQ VKGWRVPILP DRRSVRESED EDEEEEERRQ SASRGCTLQY QHATLQVFTQ
     FHTTSSEGTD QVVTMLGPDW LVEVTDLVSD FMRVGDPRVA HMVDSSTLAG LEPGTTPFKV
     VSPLTEAVLG ETLLTVTEEK VSITQLQAQV VASLALSLRP SPGSSHTILA TTAAQQTLSF
     LKQEALLSLW LSYSDGTTAP LSLYSPRDYG LLVSSLDEHV ATVTQDRAFP LVVAEAEGSG
     ELLRAELTIA ESCQKTKRKS VLATTPVGLR VHFGRDEEDP TYDYPGPSQP GPGGGEDEAR
     GAGPPGSALP APEAPGPGTA SPVVPPTEDF LPLPTGFLQV PRGLTDLEIG MYALLGVFCL
     AILVFLINCI VFVLRYRHKR IPPEGQTSMD HSHHWVFLGN GQPLRVQGEL SPPAGNPLET
     VPAFCHGDHH SSGSSQTSVQ SQVHGRGDGS SGGSARDQAE DPASSPTSKR KRVKFTTFTT
     LPSEELAYDS VPAGEEDEEE EEDLGWGCPD VAGPTRPTAP PDLHNYMRRI KEIA
//