ID   A0A0G2JSC3_HUMAN        Unreviewed;      1176 AA.
AC   A0A0G2JSC3;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 17.
DE   SubName: Full=Mucin-4 {ECO:0000313|Ensembl:ENSP00000487522};
GN   Name=MUC4 {ECO:0000313|Ensembl:ENSP00000487522};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000487522, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000487522, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000487522}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC069513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC233280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC239646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0G2JSC3; -.
DR   jPOST; A0A0G2JSC3; -.
DR   PeptideAtlas; A0A0G2JSC3; -.
DR   Ensembl; ENST00000626242; ENSP00000487522; ENSG00000277585.
DR   HGNC; HGNC:7514; MUC4.
DR   ChiTaRS; MUC4; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005176; F:ErbB-2 class receptor binding; IEA:InterPro.
DR   GO; GO:0030197; F:extracellular matrix constituent, lubricant activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0010669; P:epithelial structure maintenance; IEA:InterPro.
DR   GO; GO:0010469; P:regulation of signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR005533; AMOP_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR039898; Mucin_4.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR42668; PTHR42668; 1.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00723; AMOP; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00216; VWD; 1.
DR   PROSITE; PS50856; AMOP; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS51233; VWFD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0G2JSC3,
KW   ECO:0000213|PeptideAtlas:A0A0G2JSC3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   1176       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546738.
FT   TRANSMEM   1132   1158       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      161    316       NIDO. {ECO:0000259|PROSITE:PS51220}.
FT   DOMAIN      317    432       AMOP. {ECO:0000259|PROSITE:PS50856}.
FT   DOMAIN      445    680       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      882    921       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1085   1124       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    911    920       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1176 AA;  130473 MW;  52534C79DABF6A73 CRC64;
     MKGARWRRVP WVSLSCLCLC LLPHVVPGMT TPSLKTDGGR RTATSPPPTT SQTIISTIPS
     TAMHTRSTAA PIPILPERGV SLFPYGADAG DLEFVRRTVD FTSPLFKPAT GFPLGSSLRD
     SLYFTDNGQI IFPESDYQIF SYPNPLPTGF TGRDPVALVA PFWDDADFST GRGTTFYQEY
     ETFYGEHSLL VQQAESWIRK MTNNGGYKAR WALKVTWVNA HAYPAQWTLG SNTYQAILST
     DGSRSYALFL YQSGGMQWDV AQRSGNPVLM GFSSGDGYFE NSPLMSQPVW ERYRPDRFLN
     SNSGLQGLQF YRLHREERPN YRLECLQWLK SQPRWPSWGW NQVSCPCSWQ QGRRDLRFQP
     VSIGRWGLGS RQLCSFTSWR GGVCCSYGPW GEFREGWHVQ RPWQLAQELE PQSWCCRWND
     KPYLCALYQQ RRPHVGCATY RPPQPAWMFG DPHITTLDGV SYTFNGLGDF LLVGAQDGNS
     SFLLQGRTAQ TGSAQATNFI AFAAQYRSSS LGPVTVQWLL EPHDAIRVLL DNQTVTFQPD
     HEDGGGQETF NATGVLLSRN GSEVSASFDG WATVSVIALS NILHASASLP PEYQNRTEGL
     LGVWNNNPED DFRMPNGSTI PPGSPEEMLF HFGMTWQING TGLLGKRNDQ LPSNFTPVFY
     SQLQKNSSWA EHLISNCDGD SSCIYDTLAL RNASIGLHTR EVSKNYEQAN ATLNQYPPSI
     NGGRVIEAYK GQTTLIQYTS NAEDANFTLR DSCTDLELFE NGTLLWTPKS LEPFTLEILA
     RSAKIGLASA LQPRTVVCHC NAESQCLYNQ TSRVGNSSLE VAGCKCDGGT FGRYCEGSED
     ACEEPCFPSV HCVPGKGCEA CPPNLTGDGR HCAALGSSFL CQNQSCPVNY CYNQGHCYIS
     QTLGCQPMCT CPPAFTDSRC FLAGNNFSPT VNLELPLRVI QLLLSEEENA SMAEVNASVA
     YRLGTLDMRA FLRNSQVERI DSAAPASGSP IQHWMVISEF QYRPRGPVID FLNNQLLAAV
     VEAFLYHVPR RSEEPRNDVV FQPISGEDVR DVTALNVSTL KAYFRCDGYK GYDLVYSPQS
     GFTCVSPCSR GYCDHGGQCQ HLPSGPRCSC VSFSIYTAWG EHCEHLSMKL DAFFGIFFGA
     LGGLLLLGVG TFVVLRFWGC SGARFSYFLN SAEALP
//