ID   A0A0G2JRU8_HUMAN        Unreviewed;      1125 AA.
AC   A0A0G2JRU8;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 17.
DE   SubName: Full=Mucin-4 {ECO:0000313|Ensembl:ENSP00000487084};
GN   Name=MUC4 {ECO:0000313|Ensembl:ENSP00000487084};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000487084, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000487084, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000487084}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC069513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC233280; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC239646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A0G2JRU8; -.
DR   PeptideAtlas; A0A0G2JRU8; -.
DR   Ensembl; ENST00000626364; ENSP00000487084; ENSG00000277585.
DR   HGNC; HGNC:7514; MUC4.
DR   ChiTaRS; MUC4; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005176; F:ErbB-2 class receptor binding; IEA:InterPro.
DR   GO; GO:0030197; F:extracellular matrix constituent, lubricant activity; IEA:InterPro.
DR   GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR   GO; GO:0010669; P:epithelial structure maintenance; IEA:InterPro.
DR   GO; GO:0010469; P:regulation of signaling receptor activity; IEA:InterPro.
DR   InterPro; IPR005533; AMOP_dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR039898; Mucin_4.
DR   InterPro; IPR003886; NIDO_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR42668; PTHR42668; 1.
DR   Pfam; PF06119; NIDO; 1.
DR   Pfam; PF00094; VWD; 1.
DR   SMART; SM00723; AMOP; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00539; NIDO; 1.
DR   SMART; SM00216; VWD; 1.
DR   PROSITE; PS50856; AMOP; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS51220; NIDO; 1.
DR   PROSITE; PS51233; VWFD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0G2JRU8,
KW   ECO:0000213|PeptideAtlas:A0A0G2JRU8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29   1125       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546725.
FT   TRANSMEM   1081   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    265       NIDO. {ECO:0000259|PROSITE:PS51220}.
FT   DOMAIN      266    381       AMOP. {ECO:0000259|PROSITE:PS50856}.
FT   DOMAIN      394    629       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      831    870       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1034   1073       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    860    869       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1125 AA;  125188 MW;  119E04D2D82C1099 CRC64;
     MKGARWRRVP WVSLSCLCLC LLPHVVPGVS LFPYGADAGD LEFVRRTVDF TSPLFKPATG
     FPLGSSLRDS LYFTDNGQII FPESDYQIFS YPNPLPTGFT GRDPVALVAP FWDDADFSTG
     RGTTFYQEYE TFYGEHSLLV QQAESWIRKM TNNGGYKARW ALKVTWVNAH AYPAQWTLGS
     NTYQAILSTD GSRSYALFLY QSGGMQWDVA QRSGNPVLMG FSSGDGYFEN SPLMSQPVWE
     RYRPDRFLNS NSGLQGLQFY RLHREERPNY RLECLQWLKS QPRWPSWGWN QVSCPCSWQQ
     GRRDLRFQPV SIGRWGLGSR QLCSFTSWRG GVCCSYGPWG EFREGWHVQR PWQLAQELEP
     QSWCCRWNDK PYLCALYQQR RPHVGCATYR PPQPAWMFGD PHITTLDGVS YTFNGLGDFL
     LVGAQDGNSS FLLQGRTAQT GSAQATNFIA FAAQYRSSSL GPVTVQWLLE PHDAIRVLLD
     NQTVTFQPDH EDGGGQETFN ATGVLLSRNG SEVSASFDGW ATVSVIALSN ILHASASLPP
     EYQNRTEGLL GVWNNNPEDD FRMPNGSTIP PGSPEEMLFH FGMTWQINGT GLLGKRNDQL
     PSNFTPVFYS QLQKNSSWAE HLISNCDGDS SCIYDTLALR NASIGLHTRE VSKNYEQANA
     TLNQYPPSIN GGRVIEAYKG QTTLIQYTSN AEDANFTLRD SCTDLELFEN GTLLWTPKSL
     EPFTLEILAR SAKIGLASAL QPRTVVCHCN AESQCLYNQT SRVGNSSLEV AGCKCDGGTF
     GRYCEGSEDA CEEPCFPSVH CVPGKGCEAC PPNLTGDGRH CAALGSSFLC QNQSCPVNYC
     YNQGHCYISQ TLGCQPMCTC PPAFTDSRCF LAGNNFSPTV NLELPLRVIQ LLLSEEENAS
     MAEVNASVAY RLGTLDMRAF LRNSQVERID SAAPASGSPI QHWMVISEFQ YRPRGPVIDF
     LNNQLLAAVV EAFLYHVPRR SEEPRNDVVF QPISGEDVRD VTALNVSTLK AYFRCDGYKG
     YDLVYSPQSG FTCVSPCSRG YCDHGGQCQH LPSGPRCSCV SFSIYTAWGE HCEHLSMKLD
     AFFGIFFGAL GGLLLLGVGT FVVLRFWGCS GARFSYFLNS AEALP
//