ID A0A0G2JRU6_HUMAN Unreviewed; 392 AA. AC A0A0G2JRU6; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 16-JAN-2019, entry version 21. DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 2 {ECO:0000313|Ensembl:ENSP00000487078}; DE Flags: Fragment; GN Name=KCNQ2 {ECO:0000313|Ensembl:ENSP00000487078}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000487078, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000487078, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000487078} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00692852}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC210433; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353658; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JRU6; -. DR jPOST; A0A0G2JRU6; -. DR PeptideAtlas; A0A0G2JRU6; -. DR Ensembl; ENST00000628790; ENSP00000487078; ENSG00000281151. DR HGNC; HGNC:6296; KCNQ2. DR ChiTaRS; KCNQ2; human. DR Proteomes; UP000005640; Chromosome 20. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ. DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2. DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C. DR InterPro; IPR028325; VG_K_chnl. DR PANTHER; PTHR11537; PTHR11537; 1. DR PANTHER; PTHR11537:SF6; PTHR11537:SF6; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF03520; KCNQ_channel; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01461; KCNQ2CHANNEL. DR PRINTS; PR01459; KCNQCHANNEL. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|SAAS:SAAS00417246}; KW Ion transport {ECO:0000256|SAAS:SAAS00417246}; KW Membrane {ECO:0000256|SAAS:SAAS00417245, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417246}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417246}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JRU6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417246}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 392 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012994848. FT TRANSMEM 28 49 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 70 89 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 136 154 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 166 183 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 195 220 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 220 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT DOMAIN 350 392 KCNQ_channel. {ECO:0000259|Pfam:PF03520}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000487078}. FT NON_TER 392 392 {ECO:0000313|Ensembl:ENSP00000487078}. SQ SEQUENCE 392 AA; 44010 MW; 6C7472D1F48CC704 CRC64; XFLLVFSCLV LSVFSTIKEY EKSSEGALYI LEIVTIVVFG VEYFVRIWAA GCCCRYRGWR GRLKFARKPF CVIDIMVLIA SIAVLAAGSQ GNVFATSALR SLRFLQILRM IRMDRRGGTW KLLGSVVYAH SKELVTAWYI GFLCLILASF LVYLAEKGEN DHFDTYADAL WWGLITLTTI GYGDKYPQTW NGRLLAATFT LIGVSFFALP AGILGSGFAL KVQEQHRQKH FEKRRNPAAG LIQSAWRFYA TNLSRTDLHS TWQYYERTVT VPMYSSQTQT YGASRLIPPL NQLELLRNLK SKSGLAFRKD PPPEPSPSQK VSLKDRVFSS PRGVAAKGKG SPQAQTVRRS PSADQSLEDS PSKVPKSWSF GDRSRARQAF RIKGAASRQN SE //