ID   A0A0G2JR65_HUMAN        Unreviewed;      2817 AA.
AC   A0A0G2JR65;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 24.
DE   SubName: Full=Mucin-2 {ECO:0000313|Ensembl:ENSP00000486476};
GN   Name=MUC2 {ECO:0000313|Ensembl:ENSP00000486476};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486476, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000486476, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000486476}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00567783}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   EMBL; AC139749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0G2JR65; -.
DR   jPOST; A0A0G2JR65; -.
DR   PeptideAtlas; A0A0G2JR65; -.
DR   Ensembl; ENST00000630886; ENSP00000486476; ENSG00000278466.
DR   HGNC; HGNC:7512; MUC2.
DR   PhylomeDB; A0A0G2JR65; -.
DR   ChiTaRS; MUC2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   GO; GO:0070701; C:mucus layer; IEA:InterPro.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR028580; MUC2.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR11339:SF261; PTHR11339:SF261; 2.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF13330; Mucin2_WxxW; 1.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 4.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 4.
DR   SUPFAM; SSF57567; SSF57567; 4.
DR   PROSITE; PS01185; CTCK_1; 1.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00039,
KW   ECO:0000256|SAAS:SAAS00509702};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JR65};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00509699};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   2817       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546710.
FT   DOMAIN       36    240       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      390    604       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      859   1065       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2118   2328       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2455   2524       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     2562   2629       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN     2713   2798       CTCK. {ECO:0000259|PROSITE:PS01225}.
FT   DISULFID   2736   2790       {ECO:0000256|PROSITE-ProRule:PRU00039}.
FT   DISULFID   2740   2792       {ECO:0000256|PROSITE-ProRule:PRU00039}.
SQ   SEQUENCE   2817 AA;  303383 MW;  E0F1E70499DDC83D CRC64;
     MGLPLARLAA VCLALSLAGG SELQTEGRTR NHGHNVCSTW GNFHYKTFDG DVFRFPGLCD
     YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP
     HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE
     FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL
     VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
     YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY
     TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG
     DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNVVVF KSDGSVLLNE LQVNLPHVTA
     SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK
     TASGLVEATG AGFANTWKAQ SSCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
     CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS
     CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC
     YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR
     ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN
     TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
     SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV
     ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS
     WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC
     SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR
     SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
     SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT
     RPSTLTTFTT ITLPTTPTTF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD
     GDRETFDGVC GAPEDIECRS VKDPHLSLEQ LGQKVQCDVS VGFICKNEDQ FGNGPFGLCY
     DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TSTTTLPPTT TPSPPTTTTT TPPPTTTPSP
     PITTTTTPPP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
     SPPTTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPI TTTTTVTPTP TPTGTQTPTT
     TPITTTTTVT PTPTPTGTQT PTSTPITTTT TVTPTPTPTG TQTPTTTPIT TTTTVTPTPT
     PTGTQTPTPT AITTTTTVTP TPTPTGTQTP TTTPITTTTT VTPTPTPTGT QSPTPTAITT
     TTTVTPTPTP TGTQTPTSTP ITTTTTVTPT PTPTGTQTPT PTPISTTTTV TPTPTPTGTQ
     TPTTTPITTT TTVTPTPTPT GTQTPTTVLI TTTTTMTPTP TPTSTKSTTV TPITTTTTVT
     ATPTPTGTQT PTMIPISTTT TVTPTPTPTT GSTGPPTHTS TAPIAELTTS NPPPESSTPQ
     TSRSTSSPLT ESTTLLSTLP PAIEMTSTAP PSTPTAPTTT SGGHTLSPPP STTTSPPGTP
     TRGTTTGSSS APTPSTVQTT TTSAWTPTPT PLSTPSIIRT TGLRPYPSSV LICCVLNDTY
     YAPGEEVYNG TYGDTCYFVN CSLSCTLEFY NWSCPSTPSP TPTPSKSTPT PSKPSSTPSK
     PTPGTKPPEC PDFDPPRQEN ETWWLCDCFM ATCKYNNTVE IVKVECEPPP MPTCSNGLQP
     VRVEDPDGCC WHWECDCYCT GWGDPHYVTF DGLYYSYQGN CTYVLVEEIS PSVDNFGVYI
     DNYHCDPNDK VSCPRTLIVR HETQEVLIKT VHMMPMQVQV QVNRQAVALP YKKYGLEVYQ
     SGINYVVDIP ELGVLVSYNG LSFSVRLPYH RFGNNTKGQC GTCTNTTSDD CILPSGEIVS
     NCEAAADQWL VNDPSKPHCP HSSSTTKRPA VTVPGGGKTT PHKDCTPSPL CQLIKDSLFA
     QCHALVPPQH YYDACVFDSC FMPGSSLECA SLQAYAALCA QQNICLDWRN HTHGACLVEC
     PSHREYQACG PAEEPTCKSS SSQQNNTVLV EGCFCPEGTM NYAPGFDVCV KTCGCVGPDN
     VPREFGEHFE FDCKNCVCLE GGSGIICQPK RCSQKPVTHC VEDGTYLATE VNPADTCCNI
     TVCKCNTSLC KEKPSVCPLG FEVKSKMVPG RCCPFYWCES KGVCVHGNAE YQPGSPVYSS
     KCQDCVCTDK VDNNTLLNVI ACTHVPCNTS CSPGFELMEA PGECCKKCEQ THCIIKRPDN
     QHVILKPGDF KSDPKNNCTF FSCVKIHNQL ISSVSNITCP NFDASICIPG SITFMPNGCC
     KTCTPRNETR VPCSTVPVTT EVSYAGCTKT VLMNHCSGSC GTFVMYSAKA QALDHSCSCC
     KEEKTSQREV VLSCPNGGSL THTYTHIESC QCQDTVCGLP TGTSRRARRS PRHLGSG
//