ID A0A0G2JR54_HUMAN Unreviewed; 410 AA. AC A0A0G2JR54; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 16-JAN-2019, entry version 22. DE SubName: Full=Potassium voltage-gated channel subfamily KQT member 2 {ECO:0000313|Ensembl:ENSP00000486451}; DE Flags: Fragment; GN Name=KCNQ2 {ECO:0000313|Ensembl:ENSP00000486451}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486451, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000486451, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11780052; DOI=10.1038/414865a; RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., RA Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., RA Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., RA Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., RA Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., RA Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., RA Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., RA Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., RA Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., RA Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., RA Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., RA Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., RA Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., RA Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 20."; RL Nature 414:865-871(2001). RN [2] {ECO:0000313|Ensembl:ENSP00000486451} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the potassium channel family. CC {ECO:0000256|SAAS:SAAS00692852}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC210433; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL353658; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0G2JR54; -. DR jPOST; A0A0G2JR54; -. DR PeptideAtlas; A0A0G2JR54; -. DR Ensembl; ENST00000627948; ENSP00000486451; ENSG00000281151. DR HGNC; HGNC:6296; KCNQ2. DR ChiTaRS; KCNQ2; human. DR Proteomes; UP000005640; Chromosome 20. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro. DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ. DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2. DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C. DR InterPro; IPR028325; VG_K_chnl. DR PANTHER; PTHR11537; PTHR11537; 1. DR PANTHER; PTHR11537:SF6; PTHR11537:SF6; 1. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF03520; KCNQ_channel; 1. DR PRINTS; PR00169; KCHANNEL. DR PRINTS; PR01461; KCNQ2CHANNEL. DR PRINTS; PR01459; KCNQCHANNEL. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|SAAS:SAAS00417246}; KW Ion transport {ECO:0000256|SAAS:SAAS00417246}; KW Membrane {ECO:0000256|SAAS:SAAS00417245, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|SAAS:SAAS00417246}; KW Potassium channel {ECO:0000256|SAAS:SAAS00417246}; KW Potassium transport {ECO:0000256|SAAS:SAAS00417246}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JR54}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00417245, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417246}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 410 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5012158536. FT TRANSMEM 28 49 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 70 89 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 136 154 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 166 183 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 195 220 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 3 220 Ion_trans. {ECO:0000259|Pfam:PF00520}. FT DOMAIN 368 410 KCNQ_channel. {ECO:0000259|Pfam:PF03520}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000486451}. FT NON_TER 410 410 {ECO:0000313|Ensembl:ENSP00000486451}. SQ SEQUENCE 410 AA; 45757 MW; 2780042ED0ADAE48 CRC64; XFLLVFSCLV LSVFSTIKEY EKSSEGALYI LEIVTIVVFG VEYFVRIWAA GCCCRYRGWR GRLKFARKPF CVIDIMVLIA SIAVLAAGSQ GNVFATSALR SLRFLQILRM IRMDRRGGTW KLLGSVVYAH SKELVTAWYI GFLCLILASF LVYLAEKGEN DHFDTYADAL WWGLITLTTI GYGDKYPQTW NGRLLAATFT LIGVSFFALP AGILGSGFAL KVQEQHRQKH FEKRRNPAAG LIQSAWRFYA TNLSRTDLHS TWQYYERTVT VPMYSSQTQT YGASRLIPPL NQLELLRNLK SKSGLAFRKD PPPEPSPSKG SPCRGPLCGC CPGRSSQKVS LKDRVFSSPR GVAAKGKGSP QAQTVRRSPS ADQSLEDSPS KVPKSWSFGD RSRARQAFRI KGAASRQNSE //