ID   A0A0G2JQ44_HUMAN        Unreviewed;       651 AA.
AC   A0A0G2JQ44;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   13-FEB-2019, entry version 17.
DE   SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 1 {ECO:0000313|Ensembl:ENSP00000484936};
GN   Name=LILRB1 {ECO:0000313|Ensembl:ENSP00000484936};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484936, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484936, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484936}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
RN   [3] {ECO:0000213|PDB:6EWC}
RP   X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS) OF 27-221, AND DISULFIDE BONDS.
RX   PubMed=30365927; DOI=10.1016/j.jim.2018.10.011;
RA   Mohammed F., Stones D.H., Willcox B.E.;
RT   "Application of the immunoregulatory receptor LILRB1 as a
RT   crystallisation chaperone for human class I MHC complexes.";
RL   J. Immunol. Methods 0:0-0(2018).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; CU234142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PDB; 6EWC; X-ray; 3.20 A; D/H=27-221.
DR   PDBsum; 6EWC; -.
DR   ProteinModelPortal; A0A0G2JQ44; -.
DR   jPOST; A0A0G2JQ44; -.
DR   PeptideAtlas; A0A0G2JQ44; -.
DR   Ensembl; ENST00000613145; ENSP00000484936; ENSG00000274669.
DR   HGNC; HGNC:6605; LILRB1.
DR   ChiTaRS; LILRB1; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 4.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0000213|PDB:6EWC};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0G2JQ44,
KW   ECO:0000213|PeptideAtlas:A0A0G2JQ44};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    651       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546219.
FT   TRANSMEM    460    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       27    115       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      313    409       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DISULFID     49     98       {ECO:0000213|PDB:6EWC}.
FT   DISULFID    145    197       {ECO:0000213|PDB:6EWC}.
FT   DISULFID    157    167       {ECO:0000213|PDB:6EWC}.
SQ   SEQUENCE   651 AA;  70888 MW;  8D64D00780482C9B CRC64;
     MTPILTVLIC LGLSLGPRTH VQAGHLPKPT LWAEPGSVIT QGSPVTLRCQ GGQETQEYRL
     YREKKTAPWI TRIPQELVKK GQFPIPSITW EHAGRYRCYY GSDTAGRSES SDPLELVVTG
     AYIKPTLSAQ PSPVVNSGGN VTLQCDSQVA FDGFILCKEG EDEHPQCLNS QPHARGSSRA
     IFSVGPVSPS RRWWYRCYAY DSNSPYEWSL PSDLLELLVL GVSKKPSLSV QPGPIVAPEE
     TLTLQCGSDA GYNRFVLYKD GERDFLQLAG AQPQAGLSQA NFTLGPVSRS YGGQYRCYGA
     HNLSSEWSAP SDPLDILIAG QFYDRVSLSV QPGPTVASGE NVTLLCQSQG WMQTFLLTKE
     GAADDPWRLR STYQSQKYQA EFPMGPVTSA HAGTYRCYGS QSSKPYLLTH PSDPLELVVS
     GPSGGPSSPT TGPTSTSAGP EDQPLTPTGS DPQSGLGRHL GVVIGILVAV ILLLLLLLLL
     FLILRHRRQG KHWTSTQRKA DFQHPAGAVG PEPTDRGLQW RSSPAADAQE ENLYAAVKHT
     QPEDGVEMDT RSPHDEDPQA VTYAEVKHSR PRREMASPPS PLSGEFLDTK DRQAEEDRQM
     DTEAAASEAP QDVTYAQLHS LTLRRKATEP PPSQEGPSPA VPSIYATLAI H
//