ID   A0A0G2JPF3_HUMAN        Unreviewed;       684 AA.
AC   A0A0G2JPF3;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 17.
DE   SubName: Full=Signal peptide peptidase-like 2C {ECO:0000313|Ensembl:ENSP00000483514};
GN   Name=SPPL2C {ECO:0000313|Ensembl:ENSP00000483514};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000483514, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000483514, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000483514}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC243621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.144491; -.
DR   ProteinModelPortal; A0A0G2JPF3; -.
DR   jPOST; A0A0G2JPF3; -.
DR   PeptideAtlas; A0A0G2JPF3; -.
DR   Ensembl; ENST00000621383; ENSP00000483514; ENSG00000277106.
DR   HGNC; HGNC:28902; SPPL2C.
DR   Proteomes; UP000005640; Chromosome 17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR006639; Preselin/SPP.
DR   InterPro; IPR033150; SPPL2C.
DR   PANTHER; PTHR12174; PTHR12174; 1.
DR   PANTHER; PTHR12174:SF38; PTHR12174:SF38; 1.
DR   Pfam; PF04258; Peptidase_A22B; 1.
DR   SMART; SM00730; PSN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JPF3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    684       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546391.
FT   TRANSMEM    185    207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    280    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    494       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   684 AA;  74484 MW;  D5889C6921159E08 CRC64;
     MACLGFLLPV GFLLLISTVA GGKYGVAHVV SENWSKDYCI LFSSDYITLP RDLHHAPLLP
     LYDGTKAPWC PGEDSPHQAQ LRSPSQRPLR QTTAMVMRGN CSFHTKGWLA QGQGAHGLLI
     VSRVSDQQCS DTTLAPQDPR QPLADLTIPV AMLHYADMLD ILSHTRGEAV VRVAMYAPPE
     PIIDYNMLVI FILAVGTVAA GGYWAGLTEA NRLQRRRARR GGGSGGHHQL QEAAAAEGAQ
     KEDNEDIPVD FTPAMTGVVV TLSCSLMLLL YFFYDHFVYV TIGIFGLGAG IGLYSCLSPL
     VCHLSLRQYQ RPPHSLWASL PLPLLLLASL CATVIIFWVA YRNEDRWAWL LQDTLGISYC
     LFVLHRVRLP TLKNCSSFLL ALLAFDVFFV FVTPFFTKTG ESIMAQVALG PAESSSHERL
     PMVLKVPRLR VSALTLCSQP FSILGFGDIV VPGFLVAYCC RFDVQVCSRQ IYFVACTVAY
     AVGLLVTFMA MVLMQMGQPA LLYLVSSTLL TSLAVAACRQ ELSLFWTGQG RAKMCGLGCA
     PSAGSRQKQE GAADAHTAST LERGTSRGAG DLDSNPGEDT TEIVTISENE ATNPEDRSDS
     SEGWSDAHLD PNELPFIPPG ASEELMPLMP MAMLIPLMPL MPPPSELGHV HAQAQAHETG
     LPWAGLHKRK GLKVRKSMST QAPL
//