ID   A0A0G2JNG8_HUMAN        Unreviewed;       684 AA.
AC   A0A0G2JNG8;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 14.
DE   SubName: Full=Signal peptide peptidase-like 2C {ECO:0000313|Ensembl:ENSP00000481353};
GN   Name=SPPL2C {ECO:0000313|Ensembl:ENSP00000481353};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000481353, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000481353, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000481353}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC217770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   jPOST; A0A0G2JNG8; -.
DR   PeptideAtlas; A0A0G2JNG8; -.
DR   Ensembl; ENST00000610319; ENSP00000481353; ENSG00000278194.
DR   HGNC; HGNC:28902; SPPL2C.
DR   Proteomes; UP000005640; Chromosome 17.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR007369; Peptidase_A22B_SPP.
DR   InterPro; IPR006639; Preselin/SPP.
DR   InterPro; IPR033150; SPPL2C.
DR   PANTHER; PTHR12174; PTHR12174; 1.
DR   PANTHER; PTHR12174:SF38; PTHR12174:SF38; 1.
DR   Pfam; PF04258; Peptidase_A22B; 1.
DR   SMART; SM00730; PSN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JNG8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    684       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546245.
FT   TRANSMEM    185    207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    322    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    441    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    471    494       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   684 AA;  74639 MW;  FFBF09E7239B91F6 CRC64;
     MACLGFLLPV GFLLLISTVA GGKYGVAHVV SENWSKDYCI LFSSDYITLP RDLHHAPLLP
     LYDGTKAPWC PGEDSPHQAQ LRSPSQRPLR QTTAMVMRGN CSFHTKGWLA QGQGAHGLLI
     VSRVSDQQCS DTTLAPQDPR QPLADLTIPV AMLHYADMLD ILSHTRGEAV VRVAMYAPPE
     PIIDYNMLVI FILAVGTVAA GGYWAGLTEA NRLQRRRARR GGGPGGHHQL QEAAAAEGAQ
     KEDNEDIPVD FTPAMTGVVV TLSCSLMLLL YFFYDHFVYV TIGIFGLGAG IGLYSCLSPL
     VCRLSLRQYQ RPPHSLWASL PLPLLLLASL CTTVIIFWVA YRNEDRWAWL LQDTLGISYC
     LFVLHRVRLP TLKNCSSFLL ALLAFDVFFV FVTPFFTKTG ESIMAQVALG PAESSSHERL
     PMVLKVPRLR VSALTLCSQP FSILGFGDIV VPGFLVAYCC PFDVQVCSRQ VYFVACTVAY
     AVGLLVTFMA MVLMQMGQPA LLYLVSSTLL TSLAVAACRQ ELSLFWTGQG RAKMCGLGCA
     PSAGSRQKQE GAADAHTAST LERGTSRGAG DLDSNPGEDT TEIVTISENE ATNPEDRSDS
     PEGWSDAHLD PNELPFIPPR ASEELMPLMP MAMLIPLMPL MPRPSELGHV HAQAQAHETG
     LPWAGLHKRK GLKVRKSMST QAPL
//