ID   A0A0G2JM87_HUMAN        Unreviewed;      1779 AA.
AC   A0A0G2JM87;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 15.
DE   SubName: Full=Mucin-2 {ECO:0000313|Ensembl:ENSP00000478743};
GN   Name=MUC2 {ECO:0000313|Ensembl:ENSP00000478743};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000478743, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000478743, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000478743}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AC139749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0G2JM87; -.
DR   jPOST; A0A0G2JM87; -.
DR   PeptideAtlas; A0A0G2JM87; -.
DR   Ensembl; ENST00000622511; ENSP00000478743; ENSG00000278466.
DR   HGNC; HGNC:7512; MUC2.
DR   ChiTaRS; MUC2; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   GO; GO:0070701; C:mucus layer; IEA:InterPro.
DR   InterPro; IPR028580; MUC2.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   InterPro; IPR025155; WxxW_domain.
DR   PANTHER; PTHR11339:SF261; PTHR11339:SF261; 2.
DR   Pfam; PF08742; C8; 3.
DR   Pfam; PF13330; Mucin2_WxxW; 1.
DR   Pfam; PF01826; TIL; 2.
DR   Pfam; PF00094; VWD; 3.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF57567; SSF57567; 3.
DR   PROSITE; PS51233; VWFD; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JM87};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1779       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546171.
FT   DOMAIN       36    240       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      390    604       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      859   1065       VWFD. {ECO:0000259|PROSITE:PS51233}.
SQ   SEQUENCE   1779 AA;  191587 MW;  057867C545C8E76F CRC64;
     MGLPLARLAA VCLALSLAGG SELQTEGRTR NHGHNVCSTW GNFHYKTFDG DVFRFPGLCD
     YNFASDCRGS YKEFAVHLKR GPGQAEAPAG VESILLTIKD DTIYLTRHLA VLNGAVVSTP
     HYSPGLLIEK SDAYTKVYSR AGLTLMWNRE DALMLELDTK FRNHTCGLCG DYNGLQSYSE
     FLSDGVLFSP LEFGNMQKIN QPDVVCEDPE EEVAPASCSE HRAECERLLT AEAFADCQDL
     VPLEPYLRAC QQDRCRCPGG DTCVCSTVAE FSRQCSHAGG RPGNWRTATL CPKTCPGNLV
     YLESGSPCMD TCSHLEVSSL CEEHRMDGCF CPEGTVYDDI GDSGCVPVSQ CHCRLHGHLY
     TPGQEITNDC EQCVCNAGRW VCKDLPCPGT CALEGGSHIT TFDGKTYTFH GDCYYVLAKG
     DHNDSYALLG ELAPCGSTDK QTCLKTVVLL ADKKKNVVVF KSDGSVLLNE LQVNLPHVTA
     SFSVFRPSSY HIMVSMAIGV RLQVQLAPVM QLFVTLDQAS QGQVQGLCGN FNGLEGDDFK
     TASGLVEATG AGFANTWKAQ SSCHDKLDWL DDPCSLNIES ANYAEHWCSL LKKTETPFGR
     CHSAVDPAEY YKRCKYDTCN CQNNEDCLCA ALSSYARACT AKGVMLWGWR EHVCNKDVGS
     CPNSQVFLYN LTTCQQTCRS LSEADSHCLE GFAPVDGCGC PDHTFLDEKG RCVPLAKCSC
     YHRGLYLEAG DVVVRQEERC VCRDGRLHCR QIRLIGQSCT APKIHMDCSN LTALATSKPR
     ALSCQTLAAG YYHTECVSGC VCPDGLMDDG RGGCVVEKEC PCVHNNDLYS SGAKIKVDCN
     TCTCKRGRWV CTQAVCHGTC SIYGSGHYIT FDGKYYDFDG HCSYVAVQDY CGQNSSLGSF
     SIITENVPCG TTGVTCSKAI KIFMGRTELK LEDKHRVVIQ RDEGHHVAYT TREVGQYLVV
     ESSTGIIVIW DKRTTVFIKL APSYKGTVCG LCGNFDHRSN NDFTTRDHMV VSSELDFGNS
     WKEAPTCPDV STNPEPCSLN PHRRSWAEKQ CSILKSSVFS ICHSKVDPKP FYEACVHDSC
     SCDTGGDCEC FCSAVASYAQ ECTKEGACVF WRTPDLCPIF CDYYNPPHEC EWHYEPCGNR
     SFETCRTING IHSNISVSYL EGCYPRCPKD RPIYEEDLKK CVTADKCGCY VEDTHYPPGA
     SVPTEETCKS CVCTNSSQVV CRPEEGKILN QTQDGAFCYW EICGPNGTVE KHFNICSITT
     RPSTLTTFTT ITLPTTPTTF TTTTTTTTPT SSTVLSTTPK LCCLWSDWIN EDHPSSGSDD
     GDRETFDGVC GAPEDIECRS VKDPHLSLEQ LGQKVQCDVS VGFICKNEDQ FGNGPFGLCY
     DYKIRVNCCW PMDKCITTPS PPTTTPSPPP TSTTTLPPTT TPSPPTTTTT TPPPTTTPSP
     PITTTTTPPP TTTPSPPIST TTTPPPTTTP SPPTTTPSPP TTTPSPPTTT TTTPPPTTTP
     SPPTTTPITP PASTTTLPPT TTPSPPTTTT TTPPPTTTPI TTTTTVTPTP TPTGTQTPTT
     TPITTTTTVT PTPTPTGTQT PTSTPITTTT TTPTPTAITT TTTVTPTPTP TGTQTPTTTP
     ITTTTTVTPT PTPTGTQSPT PTAITTTTTV TPTPTPTGTQ TPTSTPITTT TTVTPTPTPT
     GTQTPTPTPI STTTTVTPTP TPTGTQTPTT TPITTTTTVT PTPTPTGTQT PTTTPTPTST
     KSTTVTPITT TTTVTATPTP TGTQTPTMIP ISTTTTVTP
//