ID   A0A0G2JKD1_HUMAN        Unreviewed;       596 AA.
AC   A0A0G2JKD1;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   16-JAN-2019, entry version 25.
DE   SubName: Full=Mucin-21 {ECO:0000313|Ensembl:ENSP00000416075};
GN   Name=MUC21 {ECO:0000313|Ensembl:ENSP00000416075};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416075, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000416075, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
RA   Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
RA   Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
RA   Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
RA   Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
RA   Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
RA   Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
RA   Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
RA   Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
RA   Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
RA   Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
RA   Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
RA   Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
RA   McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
RA   Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
RA   Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
RA   Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
RA   Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
RA   Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
RA   Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
RA   Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
RA   Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
RA   Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000416075}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; CT009610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001309299.1; NM_001322370.1.
DR   UniGene; Hs.448277; -.
DR   ProteinModelPortal; A0A0G2JKD1; -.
DR   BioMuta; ENSG00000223590; -.
DR   jPOST; A0A0G2JKD1; -.
DR   Ensembl; ENST00000457728; ENSP00000416075; ENSG00000223590.
DR   GeneID; 394263; -.
DR   CTD; 394263; -.
DR   OrthoDB; 1589631at2759; -.
DR   ChiTaRS; MUC21; human.
DR   GenomeRNAi; 394263; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022408; P:negative regulation of cell-cell adhesion; IBA:GO_Central.
DR   InterPro; IPR033534; MUC21.
DR   InterPro; IPR028199; Mucin_dom.
DR   InterPro; IPR008519; Tandem-repeating_mucin.
DR   PANTHER; PTHR39408; PTHR39408; 2.
DR   Pfam; PF14654; Epiglycanin_C; 1.
DR   Pfam; PF05647; Epiglycanin_TR; 11.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    596       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002546203.
FT   TRANSMEM    510    532       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       20     83       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN       77    134       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      109    165       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      124    181       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      154    210       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      199    257       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      254    286       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      272    331       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      332    390       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      377    430       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      423    488       Epiglycanin_TR.
FT                                {ECO:0000259|Pfam:PF05647}.
FT   DOMAIN      494    592       Epiglycanin_C.
FT                                {ECO:0000259|Pfam:PF14654}.
SQ   SEQUENCE   596 AA;  57173 MW;  B5E9FE22BC2C4FCA CRC64;
     MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA
     TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTASS GISIATNSES STTSSGASTA
     TNSESSTPSS GASTVTNSGS SVTSSGASTA TNSESSTVSS RASTATNSES STLSSGASTA
     TNSDSSTTSS GASTATNSES STTSSGASTA TNSESSTVSS RASTATNSES STTSSGASTA
     TNSESRTTSN GAGTATNSES STTSSGASTA TNSDSSTVSS GASTATNSES STTSSGASTA
     TNSESSTTSS GASTATNSDS STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA
     TNSESSTTSS GANTATNSES STVSSGASTA TNSESSTTSS GVSTATNSES STTSSGASTA
     TNSDSSTTSS EASTATNSES STVSSGISTV TNSESSTTSS GANTATNSGS SVTSAGSGTA
     ALTGMHTTSH SASTAVSEAK PGGSLVPWEI FLITLVSVVA AVGLFAGLFF CVRNSLSLRN
     TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP RWSPNWFWRR PVSSIAMEMS GRNSGP
//