ID A0A0G2JK28_HUMAN Unreviewed; 353 AA. AC A0A0G2JK28; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 16-JAN-2019, entry version 23. DE SubName: Full=Complement C2 {ECO:0000313|Ensembl:ENSP00000413482}; DE Flags: Fragment; GN Name=C2 {ECO:0000313|Ensembl:ENSP00000413482}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000413482, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000413482, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [3] {ECO:0000313|Ensembl:ENSP00000413482} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662834; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662849; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005143; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388219; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR933857; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A0G2JK28; -. DR Ensembl; ENST00000415985; ENSP00000413482; ENSG00000204364. DR Ensembl; ENST00000416456; ENSP00000404452; ENSG00000226560. DR Ensembl; ENST00000417322; ENSP00000411376; ENSG00000235696. DR Ensembl; ENST00000421932; ENSP00000410904; ENSG00000235017. DR Ensembl; ENST00000428349; ENSP00000408250; ENSG00000206372. DR Ensembl; ENST00000435104; ENSP00000413295; ENSG00000231543. DR HGNC; HGNC:1248; C2. DR ChiTaRS; C2; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro. DR CDD; cd00033; CCP; 1. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR037568; Complement_C2. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR19325:SF387; PTHR19325:SF387; 1. DR Pfam; PF00084; Sushi; 1. DR Pfam; PF00092; VWA; 1. DR SMART; SM00032; CCP; 1. DR SMART; SM00327; VWA; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR SUPFAM; SSF57535; SSF57535; 1. DR PROSITE; PS50923; SUSHI; 1. DR PROSITE; PS50234; VWFA; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302, KW ECO:0000256|SAAS:SAAS00887447}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JK28, KW ECO:0000213|PeptideAtlas:A0A0G2JK28}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 353 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514181. FT DOMAIN 17 74 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 122 320 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DISULFID 45 72 {ECO:0000256|PROSITE-ProRule:PRU00302}. FT NON_TER 353 353 {ECO:0000313|Ensembl:ENSP00000413482}. SQ SEQUENCE 353 AA; 39350 MW; F476E199D40AB0C6 CRC64; MGPLMVLFCL LFLYPAGHCP NPGISLGAVR TGFRFGHGDK VRYRCSSNLV LTGSSERECQ GNGVWSGTEP ICRQPYSYDF PEDVAPALGT SFSHMLGATN PTQKTKESLG RKIQIQRSGH LNLYLLLDCS QSVSENDFLI FKESASLMVD RIFSFEINVS VAIITFASEP KVLMSVLNDN SRDMTEVISS LENANYKDHE NGTGTNTYAA LNSVYLMMNN QMRLLGMETM AWQEIRHAII LLTDGKSNMG GSPKTAVDHI REILNINQKR NDYLDIYAIG VGKLDVDWRE LNELGSKKDG ERHAFILQDT KALHQVFEHM LDVSKLTDTI CGVGNMSANA SDQERTPWHV TIK //