ID A0A0G2JIE7_HUMAN Unreviewed; 525 AA. AC A0A0G2JIE7; DT 22-JUL-2015, integrated into UniProtKB/TrEMBL. DT 22-JUL-2015, sequence version 1. DT 16-JAN-2019, entry version 25. DE SubName: Full=Complement C2 {ECO:0000313|Ensembl:ENSP00000398098}; GN Name=C2 {ECO:0000313|Ensembl:ENSP00000398098}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000398098, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000398098, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000398098} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUN-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the peptidase S1 family. CC {ECO:0000256|SAAS:SAAS00559343}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL662834; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL662849; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL844853; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BX005143; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR388219; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759782; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR759784; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR933857; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR jPOST; A0A0G2JIE7; -. DR Ensembl; ENST00000383359; ENSP00000372850; ENSG00000204364. DR Ensembl; ENST00000383367; ENSP00000372858; ENSG00000206372. DR Ensembl; ENST00000419062; ENSP00000391314; ENSG00000235017. DR Ensembl; ENST00000423826; ENSP00000398098; ENSG00000231543. DR Ensembl; ENST00000428140; ENSP00000416484; ENSG00000226560. DR Ensembl; ENST00000452763; ENSP00000400362; ENSG00000235696. DR HGNC; HGNC:1248; C2. DR ChiTaRS; C2; human. DR Proteomes; UP000005640; Chromosome 6. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006958; P:complement activation, classical pathway; IEA:InterPro. DR CDD; cd00033; CCP; 1. DR CDD; cd00190; Tryp_SPc; 1. DR Gene3D; 3.40.50.410; -; 1. DR InterPro; IPR037568; Complement_C2. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR035976; Sushi/SCR/CCP_sf. DR InterPro; IPR000436; Sushi_SCR_CCP_dom. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR InterPro; IPR033116; TRYPSIN_SER. DR InterPro; IPR002035; VWF_A. DR InterPro; IPR036465; vWFA_dom_sf. DR PANTHER; PTHR19325:SF387; PTHR19325:SF387; 2. DR Pfam; PF00084; Sushi; 1. DR Pfam; PF00089; Trypsin; 1. DR Pfam; PF00092; VWA; 1. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00032; CCP; 1. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR SUPFAM; SSF53300; SSF53300; 1. DR SUPFAM; SSF57535; SSF57535; 1. DR PROSITE; PS50923; SUSHI; 1. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. DR PROSITE; PS00135; TRYPSIN_SER; 1. DR PROSITE; PS50234; VWFA; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302, KW ECO:0000256|SAAS:SAAS00037407}; KW Hydrolase {ECO:0000256|RuleBase:RU363034}; KW Protease {ECO:0000256|RuleBase:RU363034}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0G2JIE7, KW ECO:0000213|PeptideAtlas:A0A0G2JIE7}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Serine protease {ECO:0000256|RuleBase:RU363034}; KW Signal {ECO:0000256|SAM:SignalP}; KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}. FT SIGNAL 1 15 {ECO:0000256|SAM:SignalP}. FT CHAIN 16 525 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014514146. FT DOMAIN 13 70 Sushi. {ECO:0000259|PROSITE:PS50923}. FT DOMAIN 99 225 VWFA. {ECO:0000259|PROSITE:PS50234}. FT DOMAIN 237 517 Peptidase S1. FT {ECO:0000259|PROSITE:PS50240}. FT DISULFID 41 68 {ECO:0000256|PROSITE-ProRule:PRU00302}. SQ SEQUENCE 525 AA; 58789 MW; 98CA9CB803263B5E CRC64; MVLFCLLFLY PAGHCPNPGI SLGAVRTGFR FGHGDKVRYR CSSNLVLTGS SERECQGNGV WSGTEPICRQ PYSYDFPEDV APALGTSFSH MLGATNPTQK TKDHENGTGT NTYAALNSVY LMMNNQMRLL GMETMAWQEI RHAIILLTDG KSNMGGSPKT AVDHIREILN INQKRNDYLD IYAIGVGKLD VDWRELNELG SKKDGERHAF ILQDTKALHQ VFEHMLDVSK LTDTICGVGN MSANASDQER TPWHVTIKPK SQETCRGALI SDQWVLTAAH CFRDGNDHSL WRVNVGDPKS QWGKEFLIEK AVISPGFDVF AKKNQGILEF YGDDIALLKL AQKVKMSTHA RPICLPCTME ANLALRRPQG STCRDHENEL LNKQSVPAHF VALNGSKLNI NLKMGVEWTS CAEVVSQEKT MFPNLTDVRE VVTDQFLCSG TQEDESPCKG ESGGAVFLER RFRFFQVGLV SWGLYNPCLG SADKNSRKRA PRSKVPPPRD FHINLFRMQP WLRQHLGDVL NFLPL //