ID   A0A0D9SG88_HUMAN        Unreviewed;       449 AA.
AC   A0A0D9SG88;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   SubName: Full=Complement factor H {ECO:0000313|Ensembl:ENSP00000487250};
GN   Name=CFH {ECO:0000313|Ensembl:ENSP00000487250};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000487250, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000487250, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [3] {ECO:0000313|Ensembl:ENSP00000487250}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL049744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001014975.1; NM_001014975.2.
DR   UniGene; Hs.363396; -.
DR   ProteinModelPortal; A0A0D9SG88; -.
DR   SMR; A0A0D9SG88; -.
DR   jPOST; A0A0D9SG88; -.
DR   PeptideAtlas; A0A0D9SG88; -.
DR   PRIDE; A0A0D9SG88; -.
DR   Ensembl; ENST00000630130; ENSP00000487250; ENSG00000000971.
DR   GeneID; 3075; -.
DR   CTD; 3075; -.
DR   EuPathDB; HostDB:ENSG00000000971.15; -.
DR   HGNC; HGNC:4883; CFH.
DR   OpenTargets; ENSG00000000971; -.
DR   GeneTree; ENSGT00940000163274; -.
DR   OrthoDB; 296899at2759; -.
DR   ChiTaRS; CFH; human.
DR   GenomeRNAi; 3075; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000000971; Expressed in 206 organ(s), highest expression level in liver.
DR   ExpressionAtlas; A0A0D9SG88; baseline and differential.
DR   CDD; cd00033; CCP; 6.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00084; Sushi; 7.
DR   SMART; SM00032; CCP; 7.
DR   SUPFAM; SSF57535; SSF57535; 7.
DR   PROSITE; PS50923; SUSHI; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00887447};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0D9SG88,
KW   ECO:0000213|PeptideAtlas:A0A0D9SG88};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    449       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002346915.
FT   DOMAIN       19     82       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN       83    143       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      144    207       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      208    264       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      265    322       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      387    444       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    114    141       {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   DISULFID    178    205       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   449 AA;  51008 MW;  A9C77F0F155343F7 CRC64;
     MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY KCRPGYRSLG
     NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG GNVFEYGVKA VYTCNEGYQL
     LGEINYRECD TDGWTNDIPI CEVVKCLPVT APENGKIVSS AMEPDREYHF GQAVRFVCNS
     GYKIEGDEEM HCSDDGFWSK EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG
     YEYSERGDAV CTESGWRPLP SCEEKSCDNP YIPNGDYSPL RIKHRTGDEI TYQCRNGFYP
     ATRGNTAKCT STGWIPAPRC TLKPCDYPDI KHGGLYHENM RRPYFPVAVG KYYSYYCDEH
     FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ NHGRKFVQGK SIDVACHPGY
     ALPKAQTTVT CMENGWSPTP RCIRVSFTL
//