ID A0A0D9SFU4_HUMAN Unreviewed; 533 AA. AC A0A0D9SFU4; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 16-JAN-2019, entry version 28. DE SubName: Full=Leucine-rich glioma-inactivated protein 1 {ECO:0000313|Ensembl:ENSP00000486908}; GN Name=LGI1 {ECO:0000313|Ensembl:ENSP00000486908}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486908, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000486908, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000486908} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL157396; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL358154; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0D9SFU4; -. DR jPOST; A0A0D9SFU4; -. DR PeptideAtlas; A0A0D9SFU4; -. DR Ensembl; ENST00000629035; ENSP00000486908; ENSG00000108231. DR EuPathDB; HostDB:ENSG00000108231.11; -. DR HGNC; HGNC:6572; LGI1. DR OpenTargets; ENSG00000108231; -. DR GeneTree; ENSGT00940000159793; -. DR ChiTaRS; LGI1; human. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; ENSG00000108231; Expressed in 133 organ(s), highest expression level in caudate nucleus. DR ExpressionAtlas; A0A0D9SFU4; baseline and differential. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR000483; Cys-rich_flank_reg_C. DR InterPro; IPR009039; EAR. DR InterPro; IPR005492; EPTP. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR Pfam; PF03736; EPTP; 7. DR Pfam; PF13855; LRR_8; 1. DR SMART; SM00369; LRR_TYP; 2. DR SMART; SM00082; LRRCT; 1. DR PROSITE; PS50912; EAR; 7. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662}; KW Proteomics identification {ECO:0000213|MaxQB:A0A0D9SFU4, KW ECO:0000213|PeptideAtlas:A0A0D9SFU4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00597472}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 34 {ECO:0000256|SAM:SignalP}. FT CHAIN 35 533 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002347060. FT DOMAIN 149 198 LRRCT. {ECO:0000259|SMART:SM00082}. FT REPEAT 201 243 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 247 289 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 293 340 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 342 391 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 395 438 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 440 482 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. FT REPEAT 486 528 EAR. {ECO:0000256|PROSITE- FT ProRule:PRU00075}. SQ SEQUENCE 533 AA; 61173 MW; 52EF85975C09B9F4 CRC64; MESERSKRMG NACIPLKRIA YFLCLLSALL LTEGKKPAKP KCPAVCTCTK DNALCENARS IPRTVPPDVI SLLFTSNSFD VISDDAFIGL PHLEYLFIEN NNIKSISRHT FRGLKSLIHL SLANNNLQTL PKDIFKGLDS LTNVDLRGNS FNCDCKLKWL VEWLGHTNAT VEDIYCEGPP EYKKRKINSL SSKDFDCIIT EFAKSQDLPY QSLSIDTFSY LNDEYVVIAQ PFTGKCIFLE WDHVEKTFRN YDNITGTSTV VCKPIVIETQ LYVIVAQLFG GSHIYKRDSF ANKFIKIQDI EILKIRKPND IETFKIENNW YFVVADSSKA GFTTIYKWNG NGFYSHQSLH AWYRDTDVEY LEIVRTPQTL RTPHLILSSS SQRPVIYQWN KATQLFTNQT DIPNMEDVYA VKHFSVKGDV YICLTRFIGD SKVMKWGGSS FQDIQRMPSR GSMVFQPLQI NNYQYAILGS DYSFTQVYNW DAEKAKFVKF QELNVQAPRS FTHVSINKRN FLFASSFKGN TQIYKHVIVD LSA //