ID A0A0D9SFJ6_HUMAN Unreviewed; 62 AA. AC A0A0D9SFJ6; DT 27-MAY-2015, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 1. DT 12-SEP-2018, entry version 18. DE RecName: Full=Glycoprotein hormones alpha chain {ECO:0000256|RuleBase:RU362129}; DE Flags: Fragment; GN Name=CGA {ECO:0000313|Ensembl:ENSP00000486666}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486666, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000486666, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., RA Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., RA Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., RA Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., RA Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., RA Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., RA Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Ghori M.J., RA Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., RA Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., RA Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., RA Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., RA Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., RA Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., RA Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., RA McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., RA Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., RA Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., RA Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., RA Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., RA Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., RA Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., RA Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., RA Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., RA Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000486666} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- SUBUNIT: Heterodimer. The active hormones thyrotropin, lutropin CC and follitropin are heterodimers composed of CGA, a common alpha CC chain described here and a unique beta chain which confers their CC biological specificity to the hormones: TSHB for thyrotropin, LHB CC for lutropin and FSHB for follitropin. CC {ECO:0000256|RuleBase:RU362129}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362129, CC ECO:0000256|SAAS:SAAS00521609}. CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit alpha CC family. {ECO:0000256|RuleBase:RU362129, CC ECO:0000256|SAAS:SAAS00594029}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL138827; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; A0A0D9SFJ6; -. DR PeptideAtlas; A0A0D9SFJ6; -. DR Ensembl; ENST00000625577; ENSP00000486666; ENSG00000135346. DR EuPathDB; HostDB:ENSG00000135346.8; -. DR HGNC; HGNC:1885; CGA. DR OpenTargets; ENSG00000135346; -. DR GeneTree; ENSGT00390000012242; -. DR ChiTaRS; CGA; human. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000135346; Expressed in 91 organ(s), highest expression level in placenta. DR ExpressionAtlas; A0A0D9SFJ6; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR000476; Glyco_hormone. DR PANTHER; PTHR11509; PTHR11509; 1. DR Pfam; PF00236; Hormone_6; 1. DR PRINTS; PR00274; GLYCOHORMONE. DR SUPFAM; SSF57501; SSF57501; 1. DR PROSITE; PS50277; GLYCO_HORMONE_ALPHA_3; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00521605}; KW Glycoprotein {ECO:0000256|RuleBase:RU362129}; KW Hormone {ECO:0000256|RuleBase:RU362129, KW ECO:0000256|SAAS:SAAS00135161}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Secreted {ECO:0000256|RuleBase:RU362129, KW ECO:0000256|SAAS:SAAS00521604}; KW Signal {ECO:0000256|RuleBase:RU362129}. FT SIGNAL 1 24 {ECO:0000256|RuleBase:RU362129}. FT CHAIN 25 62 Glycoprotein hormones alpha chain. FT {ECO:0000256|RuleBase:RU362129}. FT /FTId=PRO_5005392038. FT NON_TER 62 62 {ECO:0000313|Ensembl:ENSP00000486666}. SQ SEQUENCE 62 AA; 7034 MW; 851075E8EDDA64A0 CRC64; MDYYRKYAAI FLVTLSVFLH VLHSAPDVQD CPECTLQENP FFSQPGAPIL QCMGCCFSRA YP //