ID   A0A0D9SFF4_HUMAN        Unreviewed;       459 AA.
AC   A0A0D9SFF4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   05-DEC-2018, entry version 28.
DE   SubName: Full=Neurexin-1-beta {ECO:0000313|Ensembl:ENSP00000486544};
GN   Name=NRXN1 {ECO:0000313|Ensembl:ENSP00000486544};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486544, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000486544, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000486544}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR   EMBL; AC007462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC010721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC068725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC078994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; A0A0D9SFF4; -.
DR   PeptideAtlas; A0A0D9SFF4; -.
DR   Ensembl; ENST00000628515; ENSP00000486544; ENSG00000179915.
DR   EuPathDB; HostDB:ENSG00000179915.21; -.
DR   HGNC; HGNC:8008; NRXN1.
DR   OpenTargets; ENSG00000179915; -.
DR   GeneTree; ENSGT00940000154292; -.
DR   ChiTaRS; NRXN1; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000179915; Expressed in 176 organ(s), highest expression level in corpus callosum.
DR   ExpressionAtlas; A0A0D9SFF4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR037440; Neurexin.
DR   PANTHER; PTHR44287; PTHR44287; 1.
DR   Pfam; PF02210; Laminin_G_2; 2.
DR   SMART; SM00282; LamG; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0D9SFF4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26    459       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002347055.
FT   DOMAIN       30    217       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
FT   DOMAIN      219    256       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      263    442       LAM_G_DOMAIN.
FT                                {ECO:0000259|PROSITE:PS50025}.
SQ   SEQUENCE   459 AA;  50554 MW;  D8E3B8360C9DB4B1 CRC64;
     MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT
     RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR
     RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF
     KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ
     AVCDCSRTGF RGKDCSQGKE EYIATFKGSE YFCYDLSQNP IQSSSDEITL SFKTLQRNGL
     MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV KVTRNLRQVT
     ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVNIVAIRI
     IPNSWSHHFR SSMKAPLLKT RCSRVKRHNF KFNILLLFM
//