ID A0A0D9SEP4_HUMAN Unreviewed; 1496 AA. AC A0A0D9SEP4; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 16-JAN-2019, entry version 20. DE SubName: Full=Neurexin-1-beta {ECO:0000313|Ensembl:ENSP00000485887}; GN Name=NRXN1 {ECO:0000313|Ensembl:ENSP00000485887}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000485887, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000485887, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000485887} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2015) to UniProtKB. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC007462; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007560; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007680; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007682; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC009234; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC010721; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068715; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068725; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC069550; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC078994; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001317011.1; NM_001330082.1. DR UniGene; Hs.637685; -. DR ProteinModelPortal; A0A0D9SEP4; -. DR SMR; A0A0D9SEP4; -. DR EPD; A0A0D9SEP4; -. DR Ensembl; ENST00000625672; ENSP00000485887; ENSG00000179915. DR GeneID; 9378; -. DR CTD; 9378; -. DR HGNC; HGNC:8008; NRXN1. DR OpenTargets; ENSG00000179915; -. DR eggNOG; KOG3514; Eukaryota. DR eggNOG; ENOG410XNU6; LUCA. DR OrthoDB; 35129at2759; -. DR ChiTaRS; NRXN1; human. DR GenomeRNAi; 9378; -. DR Proteomes; UP000005640; Chromosome 2. DR ExpressionAtlas; A0A0D9SEP4; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005730; C:nucleolus; IDA:HPA. DR GO; GO:0005886; C:plasma membrane; IDA:HPA. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR037440; Neurexin. DR InterPro; IPR003585; Neurexin-like. DR InterPro; IPR027789; Syndecan/Neurexin_dom. DR PANTHER; PTHR44287; PTHR44287; 2. DR Pfam; PF00008; EGF; 1. DR Pfam; PF02210; Laminin_G_2; 6. DR Pfam; PF01034; Syndecan; 1. DR SMART; SM00294; 4.1m; 1. DR SMART; SM00181; EGF; 3. DR SMART; SM00282; LamG; 6. DR SUPFAM; SSF49899; SSF49899; 6. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS50026; EGF_3; 3. DR PROSITE; PS50025; LAM_G_DOMAIN; 6. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00814887}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Membrane {ECO:0000256|SAAS:SAAS00094946, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0D9SEP4}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00094946, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00094946, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 25 {ECO:0000256|SAM:SignalP}. FT CHAIN 26 1496 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008468155. FT TRANSMEM 1422 1442 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 30 217 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 219 256 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 283 465 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 472 664 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 668 705 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 710 883 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 897 1072 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. FT DOMAIN 1075 1112 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 1118 1316 LAM_G_DOMAIN. FT {ECO:0000259|PROSITE:PS50025}. SQ SEQUENCE 1496 AA; 164428 MW; 8A9B5DA4D7783F9D CRC64; MGTALLQRGG CFLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP ATLLADTPVN DGAWHSVRIR RQFRNTTLFI DQVEAKWVEV KSKRRDMTVF SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQVLPVDSG EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF RGKDCSQEDN NVEGLAHLMM GDQGKSKGKE EYIATFKGSE YFCYDLSQNP IQSSSDEITL SFKTLQRNGL MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT LDPITFETPE SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALLK KVNDGEWYHV DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEVQSTAGV KPSCSKETAK PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL TVNLDCIRIN CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH LQSLTFNGMA YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV DSSSGLGDYL ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT DDILVASAEC PSDDEDIDPC EPSSANPTRA GGREPYPGSA EVIRESSSTT GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY ISNSAQSNGA VVKEKQPSSA KSSNKNKKNK DKEYYV //