ID   A0A0C4DH21_HUMAN        Unreviewed;       331 AA.
AC   A0A0C4DH21;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-DEC-2018, entry version 23.
DE   SubName: Full=Complement factor H-related protein 4 {ECO:0000313|Ensembl:ENSP00000356388};
GN   Name=CFHR4 {ECO:0000313|Ensembl:ENSP00000356388};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356388, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356388, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000356388}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AL139418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.710100; -.
DR   ProteinModelPortal; A0A0C4DH21; -.
DR   PeptideAtlas; A0A0C4DH21; -.
DR   Ensembl; ENST00000367418; ENSP00000356388; ENSG00000134365.
DR   EuPathDB; HostDB:ENSG00000134365.12; -.
DR   HGNC; HGNC:16979; CFHR4.
DR   OpenTargets; ENSG00000134365; -.
DR   GeneTree; ENSGT00940000154386; -.
DR   ChiTaRS; CFHR4; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000134365; Expressed in 17 organ(s), highest expression level in liver.
DR   ExpressionAtlas; A0A0C4DH21; baseline and differential.
DR   CDD; cd00033; CCP; 3.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   Pfam; PF00084; Sushi; 4.
DR   SMART; SM00032; CCP; 4.
DR   SUPFAM; SSF57535; SSF57535; 4.
DR   PROSITE; PS50923; SUSHI; 3.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00302,
KW   ECO:0000256|SAAS:SAAS00887447};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0C4DH21,
KW   ECO:0000213|PeptideAtlas:A0A0C4DH21};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    331       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002178537.
FT   DOMAIN       86    147       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      148    206       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DOMAIN      209    267       Sushi. {ECO:0000259|PROSITE:PS50923}.
FT   DISULFID    211    254       {ECO:0000256|PROSITE-ProRule:PRU00302}.
SQ   SEQUENCE   331 AA;  37325 MW;  5A0D04AB4B841424 CRC64;
     MLLLINVILT LWVSCANGQE VKPCDFPEIQ HGGLYYKSLR RLYFPAAAGQ SYSYYCDQNF
     VTPSGSYWDY IHCTQDGWLP TVPCLRTCSK SDIEIENGFI SESSSIYILN KEIQYKCKPG
     YATADGNSSG SITCLQNGWS AQPICIKFCD MPVFENSRAK SNGMRFKLHD TLDYECYDGY
     EISYGNTTGS IVCGEDGWSH FPTCYNSSEK CGPPPPISNG DTTSFLLKVY VPQSRVEYQC
     QSYYELQGSN YVTCSNGEWS EPPRCIHPCI ITEENMNKNN IQLKGKSDIK YYAKTGDTIE
     FMCKLGYNAN TSVLSFQAVC REGIVEYPRC E
//