ID   A0A0C4DGZ7_HUMAN        Unreviewed;       423 AA.
AC   A0A0C4DGZ7;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-DEC-2018, entry version 38.
DE   SubName: Full=Ankyrin repeat and death domain-containing protein 1A {ECO:0000313|Ensembl:ENSP00000484388};
GN   Name=ANKDD1A {ECO:0000313|Ensembl:ENSP00000484388};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000484388, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000484388, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000484388}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AC069368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.207157; -.
DR   Ensembl; ENST00000395720; ENSP00000379070; ENSG00000166839.
DR   Ensembl; ENST00000620154; ENSP00000484388; ENSG00000166839.
DR   EuPathDB; HostDB:ENSG00000166839.16; -.
DR   HGNC; HGNC:28002; ANKDD1A.
DR   OpenTargets; ENSG00000166839; -.
DR   eggNOG; KOG4177; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   GeneTree; ENSGT00940000154170; -.
DR   ChiTaRS; ANKDD1A; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000166839; Expressed in 179 organ(s), highest expression level in tendon.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00204; ANK; 3.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR039194; AKD1A/AKD1B.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   PANTHER; PTHR24125; PTHR24125; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00531; Death; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 9.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    423       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014222194.
FT   DOMAIN        1    287       ANK_REP_REGION.
FT                                {ECO:0000259|PROSITE:PS50297}.
FT   REPEAT       67     99       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      100    132       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      133    165       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      166    198       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      199    231       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      232    264       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   DOMAIN      336    410       Death. {ECO:0000259|PROSITE:PS50017}.
SQ   SEQUENCE   423 AA;  46551 MW;  4A01DDC3D5274D72 CRC64;
     MNALLLSAWF GHLRILQILV NSGAKIHCES KDGLTLLHCA AQKGHVPVLA FIMEDLEDVA
     LDHVDKLGRT AFHRAAEHGQ LDALDFLVGS GCDHNVKDKE GNTALHLAAG RGHMAVLQRL
     VDIGLDLEEQ NAEGLTALHS AAGGSHPDCV QLLLRAGSTV NALTQKNLSC LHYAALSGSE
     DVSRVLIHAG GCANVVDHQG ASPLHLAVRH NFPALVRLLI NSDSDVNAVD NRQQTPLHLA
     AEHAWQDIAD MLLIAGVDLN LRDKQGKTAL AVAVRSNHVS LVDMIIKADR FYRWEKDHPS
     DPSGKSLSFK QDHRQETQQL RSVLWRLASR YLQPREWKKL AYSWEFTEAH VDAIEQQWTG
     TRSYQEHGHR MLLIWLHGVA TAGENPSKAL FEGLVAIGRR DLAENIRKKA NAAPSAPRRC
     TAM
//