ID   A0A0C4DGV8_HUMAN        Unreviewed;       754 AA.
AC   A0A0C4DGV8;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   16-JAN-2019, entry version 36.
DE   SubName: Full=Semaphorin-3B {ECO:0000313|Ensembl:ENSP00000480680};
GN   Name=SEMA3B {ECO:0000313|Ensembl:ENSP00000480680};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000480680, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000480680, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000480680}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|SAAS:SAAS00692871}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; U90094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001276990.1; NM_001290061.1.
DR   UniGene; Hs.82222; -.
DR   ProteinModelPortal; A0A0C4DGV8; -.
DR   SMR; A0A0C4DGV8; -.
DR   jPOST; A0A0C4DGV8; -.
DR   PeptideAtlas; A0A0C4DGV8; -.
DR   PRIDE; A0A0C4DGV8; -.
DR   Ensembl; ENST00000611067; ENSP00000480680; ENSG00000012171.
DR   GeneID; 7869; -.
DR   CTD; 7869; -.
DR   EuPathDB; HostDB:ENSG00000012171.17; -.
DR   HGNC; HGNC:10724; SEMA3B.
DR   OpenTargets; ENSG00000012171; -.
DR   GeneTree; ENSGT00940000157756; -.
DR   OMA; LMYNSVL; -.
DR   OrthoDB; 297290at2759; -.
DR   ChiTaRS; SEMA3B; human.
DR   GenomeRNAi; 7869; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000012171; Expressed in 212 organ(s), highest expression level in tibial nerve.
DR   ExpressionAtlas; A0A0C4DGV8; baseline and differential.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF00047; ig; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00656526};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00442402};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0C4DGV8,
KW   ECO:0000213|PeptideAtlas:A0A0C4DGV8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    754       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002178529.
FT   DOMAIN       30    518       Sema. {ECO:0000259|PROSITE:PS51004}.
FT   DOMAIN      578    664       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   754 AA;  83691 MW;  E61FD08C04E9A68E CRC64;
     MGRAGAAAVI PGLALLWAVG LGSAAPSPPR LRLSFQELQA WHGLQTFSLE RTCCYQALLV
     DEERGRLFVG AENHVASLNL DNISKRAKKL AWPAPVEWRE ECNWAGKDIG TECMNFVKLL
     HAYNRTHLLA CGTGAFHPTC AFVEVGHRAE EPVLRLDPGR IEDGKGKSPY DPRHRAASVL
     VGEELYSGVA ADLMGRDFTI FRSLGQRPSL RTEPHDSRWL NEPKFVKVFW IPESENPDDD
     KIYFFFRETA VEAAPALGRL SVSRVGQICR NDVGGQRSLV NKWTTFLKAR LVCSVPGVEG
     DTHFDQLRPF PAEDVFLLSS RDHRTPLLYA VFSTSSSIFQ GSAVCVYSMN DVRRAFLGPF
     AHKEGPMHQW VSYQGRVPYP RPGMCPSKTF GTFSSTKDFP DDVIQFARNH PLMYNSVLPT
     GGRPLFLQVG ANYTFTQIAA DRVAAADGHY DVLFIGTDVG TVLKVISVPK GSRPSAEGLL
     LEELHVFEDS AAVTSMQISS KRHQLYVASR SAVAQIALHR CAAHGRVCTE CCLARDPYCA
     WDGVACTRFQ PSAKRRFRRQ DVRNGDPSTL CSGDSSRPAL LEHKVFGVEG SSAFLECEPR
     SLQARVEWTF QRAGVTAHTQ VLAEERTERT ARGLLLRRLR RRDSGVYLCA AVEQGFTQPL
     RRLSLHVLSA TQAERLARAE EAAPAAPPGP KLWYRDFLQL VEPGGGGSAN SLRMCRPQPA
     LQSLPLESRR KGRNRRTHAP EPRAERGPRS ATHW
//