ID   A0A0C4DGJ9_HUMAN        Unreviewed;       115 AA.
AC   A0A0C4DGJ9;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   16-JAN-2019, entry version 24.
DE   SubName: Full=Granzyme H {ECO:0000313|Ensembl:ENSP00000450576};
GN   Name=GZMH {ECO:0000313|Ensembl:ENSP00000450576};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000450576, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000450576, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S.,
RA   Sun H., Du H., Pepin K., Artiguenave F., Robert C., Cruaud C.,
RA   Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P.,
RA   Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N.,
RA   Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C.,
RA   Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S.,
RA   Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B.,
RA   Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M.,
RA   Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S.,
RA   Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D.,
RA   Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A.,
RA   Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L.,
RA   Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J.,
RA   Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W.,
RA   Quetier F., Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000450576}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AL136018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.348264; -.
DR   ProteinModelPortal; A0A0C4DGJ9; -.
DR   jPOST; A0A0C4DGJ9; -.
DR   PeptideAtlas; A0A0C4DGJ9; -.
DR   Ensembl; ENST00000557220; ENSP00000450576; ENSG00000100450.
DR   EuPathDB; HostDB:ENSG00000100450.12; -.
DR   HGNC; HGNC:4710; GZMH.
DR   OpenTargets; ENSG00000100450; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000153197; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000100450; Expressed in 124 organ(s), highest expression level in mononuclear cell.
DR   ExpressionAtlas; A0A0C4DGJ9; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   Pfam; PF00089; Trypsin; 2.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 2.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:A0A0C4DGJ9,
KW   ECO:0000213|PeptideAtlas:A0A0C4DGJ9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    115       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002169768.
FT   DOMAIN       20    108       Peptidase S1.
FT                                {ECO:0000259|SMART:SM00020}.
SQ   SEQUENCE   115 AA;  12678 MW;  7009A42F733515FD CRC64;
     MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG GILVRKDFVL
     TAAHCQGRGD SGGPLVCKDV AQGILSYGNK KGTPPGVYIK VSHFLPWIKR TMKRL
//