ID A0A0C4DGG6_HUMAN Unreviewed; 1286 AA. AC A0A0C4DGG6; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 16-JAN-2019, entry version 22. DE SubName: Full=NPC1-like intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSP00000438033}; GN Name=NPC1L1 {ECO:0000313|Ensembl:ENSP00000438033}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000438033, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000438033, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000438033} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC004938; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR UniGene; Hs.567486; -. DR ProteinModelPortal; A0A0C4DGG6; -. DR jPOST; A0A0C4DGG6; -. DR Ensembl; ENST00000546276; ENSP00000438033; ENSG00000015520. DR EuPathDB; HostDB:ENSG00000015520.14; -. DR HGNC; HGNC:7898; NPC1L1. DR OpenTargets; ENSG00000015520; -. DR GeneTree; ENSGT00940000159904; -. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000015520; Expressed in 76 organ(s), highest expression level in duodenum. DR ExpressionAtlas; A0A0C4DGG6; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR InterPro; IPR032190; NPC1_N. DR InterPro; IPR003392; Ptc/Disp. DR InterPro; IPR000731; SSD. DR Pfam; PF16414; NPC1_N; 1. DR Pfam; PF02460; Patched; 1. DR Pfam; PF12349; Sterol-sensing; 1. DR PROSITE; PS50156; SSD; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0C4DGG6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 1286 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002170046. FT TRANSMEM 285 305 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 351 372 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 633 654 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 666 690 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 696 719 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 739 761 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 773 797 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1067 1087 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1093 1115 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1160 1184 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1196 1219 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 632 797 SSD. {ECO:0000259|PROSITE:PS50156}. SQ SEQUENCE 1286 AA; 140390 MW; 97FB13896A811C49 CRC64; MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM TLSNVSCLSN TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF VNLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA ATLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV ARCNESQGDD VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQDI CYAPLNPDNT SLYDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL SCMADYGAPV FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ VVPFLVLSVG ADNIFIFVLE YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV ILDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL LHWITRGVVV GAPVYFVTTL GYNFSSEAGM NAICSSAGCN NFSFTQKIQY ATEFPEQSYL AIPASSWVDD FIDWLTPSSC CRLYISGPNK DKFCPSTVNS LNCLKNCMSI TMGSVRPSVE QFHKYLPWFL NDRPNIKCPK GGLAAYSTSV NLTSDGQVLA SRFMAYHKPL KNSQDYTEAL RAARELAANI TADLRKVPGT DPAFEVFPYT ITNVFYEQYL TILPEGLFML SLCLVPTFAV SCLLLGLDLR SGLLNLLSIV MILVDTVGFM ALWGISYNAV SLINLVSAVG MSVEFVSHIT RSFAISTKPT WLERAKEATI SMGSAVFAGV AMTNLPGILV LGLAKAQLIQ IFFFRLNLLI TLLGLLHGLV FLPVILSYVG PDVNPALALE QKRAEEAVAA VMVASCPNHP SRVSTADNIY VNHSFEGSIK GAGAISNFLP NNGRQF //