ID A0A0C4DGB6_HUMAN Unreviewed; 604 AA. AC A0A0C4DGB6; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 16-JAN-2019, entry version 35. DE SubName: Full=Serum albumin {ECO:0000313|Ensembl:ENSP00000422784}; GN Name=ALB {ECO:0000313|Ensembl:ENSP00000422784}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000422784, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000422784, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:18318008} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=18318008; DOI=10.1002/pmic.200700884; RA Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., RA Zou H., Gu J.; RT "Large-scale phosphoproteome analysis of human liver tissue by RT enrichment and fractionation of phosphopeptides with strong anion RT exchange chromatography."; RL Proteomics 8:1346-1361(2008). RN [3] {ECO:0000213|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:ra46-RA46(2009). RN [4] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [6] {ECO:0000213|PubMed:24129315} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24129315; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., RA Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., RA Vemulapalli V., Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). RN [7] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). RN [8] {ECO:0000313|Ensembl:ENSP00000422784} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2015) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108157; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR UniGene; Hs.418167; -. DR UniGene; Hs.592379; -. DR ProteinModelPortal; A0A0C4DGB6; -. DR SMR; A0A0C4DGB6; -. DR EPD; A0A0C4DGB6; -. DR jPOST; A0A0C4DGB6; -. DR PeptideAtlas; A0A0C4DGB6; -. DR PRIDE; A0A0C4DGB6; -. DR Ensembl; ENST00000509063; ENSP00000422784; ENSG00000163631. DR EuPathDB; HostDB:ENSG00000163631.16; -. DR HGNC; HGNC:399; ALB. DR OpenTargets; ENSG00000163631; -. DR eggNOG; ENOG410IIRZ; Eukaryota. DR eggNOG; ENOG410Z40H; LUCA. DR GeneTree; ENSGT00390000000113; -. DR ChiTaRS; ALB; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000163631; Expressed in 114 organ(s), highest expression level in right lobe of liver. DR ExpressionAtlas; A0A0C4DGB6; baseline and differential. DR GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA. DR GO; GO:0005615; C:extracellular space; IEA:InterPro. DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00015; ALBUMIN; 3. DR InterPro; IPR000264; ALB/AFP/VDB. DR InterPro; IPR020858; Serum_albumin-like. DR InterPro; IPR021177; Serum_albumin/AFP/Afamin. DR InterPro; IPR020857; Serum_albumin_CS. DR InterPro; IPR014760; Serum_albumin_N. DR PANTHER; PTHR11385; PTHR11385; 1. DR Pfam; PF00273; Serum_albumin; 3. DR PIRSF; PIRSF002520; Serum_albumin_subgroup; 1. DR PRINTS; PR00802; SERUMALBUMIN. DR SMART; SM00103; ALBUMIN; 3. DR SUPFAM; SSF48552; SSF48552; 3. DR PROSITE; PS00212; ALBUMIN_1; 1. DR PROSITE; PS51438; ALBUMIN_2; 3. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002520-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002520-1}; KW Proteomics identification {ECO:0000213|EPD:A0A0C4DGB6, KW ECO:0000213|MaxQB:A0A0C4DGB6, ECO:0000213|PeptideAtlas:A0A0C4DGB6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|PIRSR:PIRSR002520-1}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 604 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5002170196. FT DOMAIN 19 210 Albumin. {ECO:0000259|PROSITE:PS51438}. FT DOMAIN 211 403 Albumin. {ECO:0000259|PROSITE:PS51438}. FT DOMAIN 404 599 Albumin. {ECO:0000259|PROSITE:PS51438}. FT METAL 91 91 Zinc. {ECO:0000256|PIRSR:PIRSR002520-1}. FT METAL 123 123 Zinc. {ECO:0000256|PIRSR:PIRSR002520-1}. FT METAL 271 271 Zinc. {ECO:0000256|PIRSR:PIRSR002520-1}. FT METAL 273 273 Zinc. {ECO:0000256|PIRSR:PIRSR002520-1}. FT BINDING 264 264 Bilirubin. FT {ECO:0000256|PIRSR:PIRSR002520-3}. FT SITE 223 223 Aspirin-acetylated lysine. FT {ECO:0000256|PIRSR:PIRSR002520-4}. FT DISULFID 77 86 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 99 115 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 114 125 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 148 193 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 192 201 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 224 270 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 269 277 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 289 303 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 302 313 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 340 385 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 384 393 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 416 462 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 461 472 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 485 501 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 500 511 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 538 583 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 582 591 {ECO:0000256|PIRSR:PIRSR002520-2}. SQ SEQUENCE 604 AA; 69227 MW; 8682AE2D8E108F13 CRC64; MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEPTMRI RERK //