ID A0A0C4DG16_HUMAN Unreviewed; 474 AA. AC A0A0C4DG16; DT 01-APR-2015, integrated into UniProtKB/TrEMBL. DT 01-APR-2015, sequence version 1. DT 13-FEB-2019, entry version 42. DE SubName: Full=Calcitonin receptor {ECO:0000313|Ensembl:ENSP00000389295}; GN Name=CALCR {ECO:0000313|Ensembl:ENSP00000389295}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389295, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000389295, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000313|Ensembl:ENSP00000389295} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2015) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. CC {ECO:0000256|SAAS:SAAS00547938}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC003078; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC005024; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001158210.1; NM_001164738.1. DR RefSeq; NP_001733.1; NM_001742.3. DR UniGene; Hs.489127; -. DR Ensembl; ENST00000394441; ENSP00000377959; ENSG00000004948. DR Ensembl; ENST00000426151; ENSP00000389295; ENSG00000004948. DR GeneID; 799; -. DR CTD; 799; -. DR EuPathDB; HostDB:ENSG00000004948.13; -. DR HGNC; HGNC:1440; CALCR. DR OpenTargets; ENSG00000004948; -. DR eggNOG; KOG4564; Eukaryota. DR eggNOG; ENOG410XRS2; LUCA. DR GeneTree; ENSGT00940000155380; -. DR OrthoDB; 1005634at2759; -. DR ChiTaRS; CALCR; human. DR GenomeRNAi; 799; -. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000004948; Expressed in 52 organ(s), highest expression level in tibia. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004948; F:calcitonin receptor activity; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro. DR CDD; cd15274; 7tmB1_calcitonin_R; 1. DR Gene3D; 4.10.1240.10; -; 1. DR InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam. DR InterPro; IPR017981; GPCR_2-like. DR InterPro; IPR001688; GPCR_2_calcitonin_rcpt. DR InterPro; IPR036445; GPCR_2_extracell_dom_sf. DR InterPro; IPR001879; GPCR_2_extracellular_dom. DR InterPro; IPR000832; GPCR_2_secretin-like. DR InterPro; IPR017983; GPCR_2_secretin-like_CS. DR PANTHER; PTHR12011:SF84; PTHR12011:SF84; 1. DR Pfam; PF00002; 7tm_2; 1. DR Pfam; PF02793; HRM; 1. DR PRINTS; PR00361; CALCITONINR. DR PRINTS; PR01350; CTRFAMILY. DR PRINTS; PR00249; GPCRSECRETIN. DR SMART; SM00008; HormR; 1. DR SUPFAM; SSF111418; SSF111418; 1. DR PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1. DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1. DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1. DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998}; KW Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A0C4DG16}; KW Receptor {ECO:0000256|SAAS:SAAS00978998}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|SAAS:SAAS00978998}; KW Transmembrane {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00501090, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 474 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014509641. FT TRANSMEM 147 176 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 188 206 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 234 254 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 261 284 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 296 320 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 341 362 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 374 394 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 54 138 G_PROTEIN_RECEP_F2_3. FT {ECO:0000259|PROSITE:PS50227}. FT DOMAIN 148 395 G_PROTEIN_RECEP_F2_4. FT {ECO:0000259|PROSITE:PS50261}. SQ SEQUENCE 474 AA; 55345 MW; 0D9FA81230B282D9 CRC64; MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR PSNRSARAAA AAAEAGDIPI YICHQELRNE PANNQGEESA EIIPLNIIEQ ESSA //