ID   A0A0C4DFZ5_HUMAN        Unreviewed;       399 AA.
AC   A0A0C4DFZ5;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-DEC-2018, entry version 26.
DE   SubName: Full=Ankyrin repeat and death domain-containing protein 1A {ECO:0000313|Ensembl:ENSP00000379073};
GN   Name=ANKDD1A {ECO:0000313|Ensembl:ENSP00000379073};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000379073, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000379073, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000379073}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AC069368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC103691; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.207157; -.
DR   ProteinModelPortal; A0A0C4DFZ5; -.
DR   Ensembl; ENST00000395723; ENSP00000379073; ENSG00000166839.
DR   EuPathDB; HostDB:ENSG00000166839.16; -.
DR   HGNC; HGNC:28002; ANKDD1A.
DR   OpenTargets; ENSG00000166839; -.
DR   GeneTree; ENSGT00940000154170; -.
DR   ChiTaRS; ANKDD1A; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000166839; Expressed in 179 organ(s), highest expression level in tendon.
DR   ExpressionAtlas; A0A0C4DFZ5; baseline and differential.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00204; ANK; 2.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR039194; AKD1A/AKD1B.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   PANTHER; PTHR24125; PTHR24125; 2.
DR   Pfam; PF12796; Ank_2; 2.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 8.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    399       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002169753.
FT   DOMAIN        1    264       ANK_REP_REGION.
FT                                {ECO:0000259|PROSITE:PS50297}.
FT   REPEAT       67     99       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      100    132       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      133    165       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      166    198       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      199    231       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   REPEAT      232    264       ANK. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00023}.
FT   DOMAIN      304    371       Death. {ECO:0000259|PROSITE:PS50017}.
SQ   SEQUENCE   399 AA;  43724 MW;  758E8AC2B8358EA7 CRC64;
     MNALLLSAWF GHLRILQILV NSGAKIHCES KDGLTLLHCA AQKGHVPVLA FIMEDLEDVA
     LDHVDKLGRT AFHRAAEHGQ LDALDFLVGS GCDHNVKDKE GNTALHLAAG RGHMAVLQRL
     VDIGLDLEEQ NAEGLTALHS AAGGSHPDCV QLLLRAGSTV NALTQKNLSC LHYAALSGSE
     DVSRVLIHAG GCANVVDHQG ASPLHLAVRH NFPALVRLLI NSDSDVNAVD NRQQTPLHLA
     AEHAWQDIAD MLLIAGVDLN LRDKDHPSDP SGKSLSFKQD HRQETQQLRS VLWRLASRYL
     QPREWKKLAY SWEFTEAHVD AIEQQWTGTR SYQEHGHRML LIWLHGVATA GENPSKALFE
     GLVAIGRRDL AGWSTMARSQ LTATSASRVQ MILVPQPPE
//