ID   A0A0C4DFX6_HUMAN        Unreviewed;      1332 AA.
AC   A0A0C4DFX6;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   16-JAN-2019, entry version 32.
DE   SubName: Full=NPC1-like intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSP00000370552};
GN   Name=NPC1L1 {ECO:0000313|Ensembl:ENSP00000370552};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000370552, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000370552, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000370552}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
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DR   EMBL; AC004938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001095118.1; NM_001101648.1.
DR   UniGene; Hs.567486; -.
DR   ProteinModelPortal; A0A0C4DFX6; -.
DR   SMR; A0A0C4DFX6; -.
DR   jPOST; A0A0C4DFX6; -.
DR   PRIDE; A0A0C4DFX6; -.
DR   Ensembl; ENST00000381160; ENSP00000370552; ENSG00000015520.
DR   GeneID; 29881; -.
DR   CTD; 29881; -.
DR   EuPathDB; HostDB:ENSG00000015520.14; -.
DR   HGNC; HGNC:7898; NPC1L1.
DR   OpenTargets; ENSG00000015520; -.
DR   eggNOG; KOG1933; Eukaryota.
DR   eggNOG; ENOG410XR54; LUCA.
DR   GeneTree; ENSGT00940000159904; -.
DR   OrthoDB; 731120at2759; -.
DR   GenomeRNAi; 29881; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000015520; Expressed in 76 organ(s), highest expression level in duodenum.
DR   ExpressionAtlas; A0A0C4DFX6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR   InterPro; IPR004765; NPC1-like.
DR   InterPro; IPR032190; NPC1_N.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   Pfam; PF16414; NPC1_N; 1.
DR   Pfam; PF02460; Patched; 1.
DR   Pfam; PF12349; Sterol-sensing; 1.
DR   TIGRFAMs; TIGR00917; 2A060601; 1.
DR   PROSITE; PS50156; SSD; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0C4DFX6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22   1332       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002178504.
FT   TRANSMEM    285    305       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    633    654       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    666    690       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    696    719       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    739    761       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    773    797       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    848    869       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1113   1133       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1139   1161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1206   1230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1242   1265       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      632    797       SSD. {ECO:0000259|PROSITE:PS50156}.
SQ   SEQUENCE   1332 AA;  145764 MW;  EFE94F80309C3BF2 CRC64;
     MAEAGLRGWL LWALLLRLAQ SEPYTTIHQP GYCAFYDECG KNPELSGSLM TLSNVSCLSN
     TPARKITGDH LILLQKICPR LYTGPNTQAC CSAKQLVSLE ASLSITKALL TRCPACSDNF
     VNLHCHNTCS PNQSLFINVT RVAQLGAGQL PAVVAYEAFY QHSFAEQSYD SCSRVRVPAA
     ATLAVGTMCG VYGSALCNAQ RWLNFQGDTG NGLAPLDITF HLLEPGQAVG SGIQPLNEGV
     ARCNESQGDD VATCSCQDCA ASCPAIARPQ ALDSTFYLGQ MPGSLVLIII LCSVFAVVTI
     LLVGFRVAPA RDKSKMVDPK KGTSLSDKLS FSTHTLLGQF FQGWGTWVAS WPLTILVLSV
     IPVVALAAGL VFTELTTDPV ELWSAPNSQA RSEKAFHDQH FGPFFRTNQV ILTAPNRSSY
     RYDSLLLGPK NFSGILDLDL LLELLELQER LRHLQVWSPE AQRNISLQDI CYAPLNPDNT
     SLYDCCINSL LQYFQNNRTL LLLTANQTLM GQTSQVDWKD HFLYCANAPL TFKDGTALAL
     SCMADYGAPV FPFLAIGGYK GKDYSEAEAL IMTFSLNNYP AGDPRLAQAK LWEEAFLEEM
     RAFQRRMAGM FQVTFMAERS LEDEINRTTA EDLPIFATSY IVIFLYISLA LGSYSSWSRV
     MVDSKATLGL GGVAVVLGAV MAAMGFFSYL GIRSSLVILQ VVPFLVLSVG ADNIFIFVLE
     YQRLPRRPGE PREVHIGRAL GRVAPSMLLC SLSEAICFFL GALTPMPAVR TFALTSGLAV
     ILDFLLQMSA FVALLSLDSK RQEASRLDVC CCVKPQELPP PGQGEGLLLG FFQKAYAPFL
     LHWITRGVVL LLFLALFGVS LYSMCHISVG LDQELALPKD SYLLDYFLFL NRYFEVGAPV
     YFVTTLGYNF SSEAGMNAIC SSAGCNNFSF TQKIQYATEF PEQSYLAIPA SSWVDDFIDW
     LTPSSCCRLY ISGPNKDKFC PSTVNSLNCL KNCMSITMGS VRPSVEQFHK YLPWFLNDRP
     NIKCPKGGLA AYSTSVNLTS DGQVLASRFM AYHKPLKNSQ DYTEALRAAR ELAANITADL
     RKVPGTDPAF EVFPYTITNV FYEQYLTILP EGLFMLSLCL VPTFAVSCLL LGLDLRSGLL
     NLLSIVMILV DTVGFMALWG ISYNAVSLIN LVSAVGMSVE FVSHITRSFA ISTKPTWLER
     AKEATISMGS AVFAGVAMTN LPGILVLGLA KAQLIQIFFF RLNLLITLLG LLHGLVFLPV
     ILSYVGPDVN PALALEQKRA EEAVAAVMVA SCPNHPSRVS TADNIYVNHS FEGSIKGAGA
     ISNFLPNNGR QF
//